LGMN

Gene Symbol LGMN
Entrez Gene 5641
Alt Symbol AEP, LGMN1, PRSC1
Species Human
Gene Type protein-coding
Description legumain
Other Description asparaginyl endopeptidase|cysteine protease 1|protease, cysteine 1|protease, cysteine, 1 (legumain)
Swissprots O00123 Q86TV3 Q99538 Q9BTY1 Q86TV2
Accessions CAS91767 CAS91768 CAS91772 EAW81500 EAW81501 Q99538 AK225822 AK291534 BAF84223 AK291560 BAF84249 AK297074 BAH12490 AK297780 BAH12664 BC003061 AAH03061 BC013678 AAH13678 BM838821 BX161380 CAD61872 BX161422 CAD61895 BX161434 CAD61906 CD366588 CR457406 CAG33687 D55696 BAA09530 DA347449 DQ891884 ABM82810 DQ895070 ABM85996 DQ895071 ABM85997 EU176651 ABW03452 Y09862 CAA70989 XM_005267862 XP_005267919 XM_005267863 XP_005267920 XM_011536970 XP_011535272 NM_001008530 NP_001008530 NM_005606 NP_005597
Function Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation (By similarity). May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system. {ECO:0000250, ECO:0000269|PubMed:23776206}.
Subcellular Location Lysosome {ECO:0000250}.
Tissue Specificity Ubiquitous. Particularly abundant in kidney, heart and placenta.
Top Pathways Lysosome, Antigen processing and presentation

Legumain (F-10) - sc-271312 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Legumain (F-10): sc-271312. Western blot analysis of Legumain expression in non-transfected CHO: sc-117750 (A), human Legumain transfected CHO: sc-110066 (B) and JAR (C) whole cell lysates.

Legumain (B-8) - sc-133234 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Legumain (B-8): sc-133234. Immunoperoxidase staining of formalin fixed, paraffin-embedded human placenta tissue showing cytoplasmic staining of trophoblastic cells.

Legumain (B-10) - sc-166971 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Legumain (B-10): sc-166971. Western blot analysis of Legumain expression in non-transfected: sc-117750 (A) and human Legumain transfected: sc-110066 (B) CHO whole cell lysates.

Legumain (B-11) - sc-133124 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Legumain (B-11): sc-133124. Western blot analysis of Legumain expression in non-transfected CHO: sc-117750 (A), human Legumain transfected CHO: sc-110066 (B), JEG-3 (C) and JAR (D) whole cell lysates.

Legumain (H-300) - sc-67163 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Legumain (H-300): sc-67163. Western blot analysis of Legumain expression in KNRK (A) and Caki-1 (B) whole cell lysates.

Legumain (K-15) - sc-47104 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Legumain (K-15): sc-47104. Western blot analysis of Legumain expression in non-transfected: sc-110760 (A) and human Legumain transfected: sc-159634 (B) 293 whole cell lysates.

Legumain (N-15) - sc-47105 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Legumain (N-15): sc-47105. Western blot analysis of Legumain expression in non-transfected: sc-117750 (A) and human Legumain transfected: sc-110066 (B) CHO whole cell lysates.

Legumain (K-12) - sc-47103 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-Legumain antibody - ab125286 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Legumain antibody (ab125286) at 1/500 dilutionLane 1 : HT29 cell lysateLane 2 : HeLa cell lysateLane 3 : Mouse Kidney lysate

Anti-Legumain antibody - ab47146 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Legumain antibody (ab47146) at 1/1000 dilutionLane 1 : Whole cell lysate prepared from Madin Darby canine kidney (MDCK) cells (treated with SF) Lane 2 : Whole cell lysate prepared from Madin Darby canine kidney (MDCK) cells (treated with TPA) Lane 3 : Whole cell lysate prepared from Madin Darby canine kidney (MDCK) cells (treated with IL1-beta) Lane 4 : Whole cell lysate prepared from Madin Darby canine kidney (MDCK) cells (treated with TNF-alpha)

Anti-Legumain antibody - ab47157 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Legumain antibody (ab47157) at 1/1000 dilutionLane 1 : Recombinant Human Legumain at 0.04 µgLane 2 : Recombinant Human Legumain at 0.02 µgLane 3 : Recombinant Human Legumain at 0.01 µgLane 4 : Recombinant Human Legumain at 0.004 µgLane 5 : Recombinant Human Legumain at 0.002 µgLane 6 : Recombinant Human Legumain at 0.001 µg

Anti-Legumain antibody [EPR14718] - ab183028 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR14718
All lanes : Anti-Legumain antibody [EPR14718] (ab183028) at 1/10000 dilutionLane 1 : Human fetal kidney lysateLane 2 : JAR cell ysateLane 3 : HeLa cell lysateLane 4 : 293 cell lysateLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-Legumain antibody [MM0625-46I3] - ab135202 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone MM0625-46I3

Anti-Legumain antibody - Carboxyterminal end - ab47138 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Legumain antibody - Carboxyterminal end (ab47138) at 1/1000 dilutionLane 1 : Recombinant Human Legumain at 0.04 µgLane 2 : Recombinant Human Legumain at 0.02 µgLane 3 : Recombinant Human Legumain at 0.01 µgLane 4 : Recombinant Human Legumain at 0.004 µg

Anti-LGMN / Legumain Antibody (aa83-112, AP) - LS-C261859 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LGMN / Legumain Antibody (aa83-112, APC) - LS-C261860 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LGMN / Legumain Antibody (aa83-112, Biotin) - LS-C261861 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LGMN / Legumain Antibody (aa83-112, Azide-free, HRP) - LS-C261863 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LGMN / Legumain Antibody (aa1-434, clone M1) - LS-C309173 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone M1

Anti-LGMN / Legumain Antibody (aa83-112, PE) - LS-C261865 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LGMN / Legumain Antibody (aa181-230) - LS-C152205 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
LGMN / Legumain antibody Western Blot of HepG2.

Anti-LGMN / Legumain Antibody (aa214-263) - LS-C152206 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
LGMN / Legumain antibody Western Blot of Fetal Brain.

Anti-LGMN / Legumain Antibody - LS-C309174 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-LGMN / Legumain Antibody - LS-C310868 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-LGMN / Legumain Antibody (aa83-112) - LS-C322638 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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