LGMN

Gene Symbol	LGMN
Entrez Gene	5641
Alt Symbol	AEP, LGMN1, PRSC1
Species	Human
Gene Type	protein-coding
Description	legumain
Other Description	asparaginyl endopeptidase|cysteine protease 1|protease, cysteine 1|protease, cysteine, 1 (legumain)
Swissprots	O00123 Q86TV3 Q99538 Q9BTY1 Q86TV2
Accessions	CAS91767 CAS91768 CAS91772 EAW81500 EAW81501 Q99538 AK225822 AK291534 BAF84223 AK291560 BAF84249 AK297074 BAH12490 AK297780 BAH12664 BC003061 AAH03061 BC013678 AAH13678 BM838821 BX161380 CAD61872 BX161422 CAD61895 BX161434 CAD61906 CD366588 CR457406 CAG33687 D55696 BAA09530 DA347449 DQ891884 ABM82810 DQ895070 ABM85996 DQ895071 ABM85997 EU176651 ABW03452 Y09862 CAA70989 XM_005267862 XP_005267919 XM_005267863 XP_005267920 XM_011536970 XP_011535272 NM_001008530 NP_001008530 NM_005606 NP_005597
Function	Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation (By similarity). May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system. {ECO:0000250, ECO:0000269|PubMed:23776206}.
Subcellular Location	Lysosome {ECO:0000250}.
Tissue Specificity	Ubiquitous. Particularly abundant in kidney, heart and placenta.
Top Pathways	Lysosome, Antigen processing and presentation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Legumain full length protein - ab132514 from Abcam Category Protein Source Wheat germ Species Human

Human Legumain full length protein - ab151680 from Abcam Category Protein Source HEK 293 cells Species Human

Human Legumain full length protein - ab198767 from Abcam Category Protein Source E. coli Species Human

Legumain peptide - ab47298 from Abcam Category Peptide

LGMN / Legumain Antibody Blocking Peptide - LS-E24171 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

LGMN / Legumain Antibody Blocking Peptide - LS-E24170 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Legumain/Asparaginyl Endopeptidase Protein - H00005641-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Legumain/Asparaginyl Endopeptidase, CF - 2199-CY-010 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Ile18-Tyr433, with an N-terminal 7-His tag

Human Legumain protein - orb49502 from Biorbyt Category Protein Prices $408.00, $595.00, $1,904.00, $2,695.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

Legumain - H00005641-P01-10 from Acris Antibodies Category Protein Source in vitro transl. Species Human

Legumain - H00005641-P01-25 from Acris Antibodies Category Protein Source in vitro transl. Species Human

Legumain, Human, Recombinant - 19-C371 from ARP American Research Products Category Protein Prices $169.00 Sizes 10 µg Source HEK293 Species Human

LGMN fusion protein - ag7218 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

LGMN fusion protein - ag7170 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human Legumain Protein - BP001740-C371 from Syd Labs Category Protein Prices $180.00, $528.00, $2,640.00 Sizes 10 µg, 50 µg, 1 mg Source HEK 293-derived. Species Human

Recombinant Human LGMN, His-tagged - LGMN-7977H from Creative Biomart Category Protein Source HEK293 Cells Species Human

Recombinant Human LGMN, His-tagged - LGMN-7980H from Creative Biomart Category Protein Source Mouse NSO Cells Species Human

Recombinant Legumain (LGMN) - RPC564Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Legumain (LGMN) - RPC564Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Legumain (LGMN) - RPC564Mu02 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Legumain (LGMN) - RPC564Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Legumain(LGMN) - CSB-YP012903HU CSB-EP012903HU CSB-BP012903HU CSB-MP012903HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Legumain, 18-433aa, Human, His tag, Baculovirus - ATGP3185 from ATGen Category Protein Prices $80.00, $240.00, $960.00 Sizes 10 µg, 50 µg, 250 µg Species Human

Legumain protein - 80R-4330 from Fitzgerald Category Protein Prices $275.00 Sizes 50 µg Source Insect cells

Legumain - H00005641-P01 from Acris Antibodies Category Protein Prices $350.00 Sizes 2 µg Source in vitro transl. Species Human

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