LGMN

Gene Symbol LGMN
Entrez Gene 5641
Alt Symbol AEP, LGMN1, PRSC1
Species Human
Gene Type protein-coding
Description legumain
Other Description asparaginyl endopeptidase|cysteine protease 1|protease, cysteine 1|protease, cysteine, 1 (legumain)
Swissprots O00123 Q86TV3 Q99538 Q9BTY1 Q86TV2
Accessions CAS91767 CAS91768 CAS91772 EAW81500 EAW81501 Q99538 AK225822 AK291534 BAF84223 AK291560 BAF84249 AK297074 BAH12490 AK297780 BAH12664 BC003061 AAH03061 BC013678 AAH13678 BM838821 BX161380 CAD61872 BX161422 CAD61895 BX161434 CAD61906 CD366588 CR457406 CAG33687 D55696 BAA09530 DA347449 DQ891884 ABM82810 DQ895070 ABM85996 DQ895071 ABM85997 EU176651 ABW03452 Y09862 CAA70989 XM_005267862 XP_005267919 XM_005267863 XP_005267920 XM_011536970 XP_011535272 NM_001008530 NP_001008530 NM_005606 NP_005597
Function Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation (By similarity). May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system. {ECO:0000250, ECO:0000269|PubMed:23776206}.
Subcellular Location Lysosome {ECO:0000250}.
Tissue Specificity Ubiquitous. Particularly abundant in kidney, heart and placenta.
Top Pathways Lysosome, Antigen processing and presentation

Legumain CRISPR/Cas9 KO Plasmid (h) - sc-402437 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Legumain HDR Plasmid (h) - sc-402437-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Legumain Double Nickase Plasmid (h) - sc-402437-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Legumain Double Nickase Plasmid (h2) - sc-402437-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Legumain CRISPR Activation Plasmid (h) - sc-402437-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Legumain CRISPR Activation Plasmid (h2) - sc-402437-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Legumain Lentiviral Activation Particles (h) - sc-402437-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Legumain Lentiviral Activation Particles (h2) - sc-402437-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Legumain siRNA (h) - sc-60930 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Legumain shRNA Plasmid (h) - sc-60930-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Legumain shRNA (h) Lentiviral Particles - sc-60930-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Legumain/Asparaginyl Endopeptidase RNAi - H00005641-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

Legumain/Asparaginyl Endopeptidase RNAi - H00005641-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU113981 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN11680 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11680 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR03948 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr03948

LGMN siRNA (Human) - CRH3802 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human LGMN (NM_005606.6) - SHH329931 from Creative biogene

Category siRNA
Species Reactivities Human

Human LGMN siRNA - orb264304 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

LGMN shRNA Plasmid (Human) - CHH3802 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

LGMN miRNA 3'UTR clone - MiUTR3H-05138 from Creative biogene

Species Reactivities Human

LGMN miRNA 3'UTR clone - MiUTR3H-05139 from Creative biogene

Species Reactivities Human
Search more