| Gene Symbol |
LGMN
|
| Entrez Gene |
5641
|
| Alt Symbol |
AEP, LGMN1, PRSC1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
legumain
|
| Other Description |
asparaginyl endopeptidase|cysteine protease 1|protease, cysteine 1|protease, cysteine, 1 (legumain)
|
| Swissprots |
O00123 Q86TV3 Q99538 Q9BTY1 Q86TV2
|
| Accessions |
CAS91767 CAS91768 CAS91772 EAW81500 EAW81501 Q99538 AK225822 AK291534 BAF84223 AK291560 BAF84249 AK297074 BAH12490 AK297780 BAH12664 BC003061 AAH03061 BC013678 AAH13678 BM838821 BX161380 CAD61872 BX161422 CAD61895 BX161434 CAD61906 CD366588 CR457406 CAG33687 D55696 BAA09530 DA347449 DQ891884 ABM82810 DQ895070 ABM85996 DQ895071 ABM85997 EU176651 ABW03452 Y09862 CAA70989 XM_005267862 XP_005267919 XM_005267863 XP_005267920 XM_011536970 XP_011535272 NM_001008530 NP_001008530 NM_005606 NP_005597
|
| Function |
Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation (By similarity). May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system. {ECO:0000250, ECO:0000269|PubMed:23776206}.
|
| Subcellular Location |
Lysosome {ECO:0000250}.
|
| Tissue Specificity |
Ubiquitous. Particularly abundant in kidney, heart and placenta.
|
| Top Pathways |
Lysosome, Antigen processing and presentation
|
![Western Blot: Legumain Overexpression Lysate (Adult Normal) [NBL1-12508] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Legumain.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/864_Legumain%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-12508-img0002.jpg)
![Western Blot: Legumain Overexpression Lysate (Adult Normal) [NBP2-11310] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Legumain.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2378_Legumain%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-11310-img0001.jpg)
![Western Blot: Legumain Overexpression Lysate (Adult Normal) [NBP2-10455] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Legumain.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/10370_Legumain%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-10455-img0001.jpg)