LGMN

Gene Symbol	LGMN
Entrez Gene	5641
Alt Symbol	AEP, LGMN1, PRSC1
Species	Human
Gene Type	protein-coding
Description	legumain
Other Description	asparaginyl endopeptidase|cysteine protease 1|protease, cysteine 1|protease, cysteine, 1 (legumain)
Swissprots	O00123 Q86TV3 Q99538 Q9BTY1 Q86TV2
Accessions	CAS91767 CAS91768 CAS91772 EAW81500 EAW81501 Q99538 AK225822 AK291534 BAF84223 AK291560 BAF84249 AK297074 BAH12490 AK297780 BAH12664 BC003061 AAH03061 BC013678 AAH13678 BM838821 BX161380 CAD61872 BX161422 CAD61895 BX161434 CAD61906 CD366588 CR457406 CAG33687 D55696 BAA09530 DA347449 DQ891884 ABM82810 DQ895070 ABM85996 DQ895071 ABM85997 EU176651 ABW03452 Y09862 CAA70989 XM_005267862 XP_005267919 XM_005267863 XP_005267920 XM_011536970 XP_011535272 NM_001008530 NP_001008530 NM_005606 NP_005597
Function	Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation (By similarity). May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system. {ECO:0000250, ECO:0000269|PubMed:23776206}.
Subcellular Location	Lysosome {ECO:0000250}.
Tissue Specificity	Ubiquitous. Particularly abundant in kidney, heart and placenta.
Top Pathways	Lysosome, Antigen processing and presentation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human-LGMN-cDNA-Clone - DC01220 from Abgent, a WuXi AppTec company Prices $584.55 Sizes 10 µg Species Human Accession BC003061

LGMN - MBS1272632 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC003061

Human LGMN ORF Clone(NM_001008530.2) - CDCL168624 from Creative Biomart Species Human Accession NM_001008530.2

Human Legumain Gene ORF cDNA clone in cloning vector - HG12846-G from Sino Biological Species Human

Human Legumain Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG12846-ACG from Sino Biological Species Human

Human Legumain Gene ORF cDNA clone expression plasmid, C-HA tag - HG12846-CY from Sino Biological Species Human

Human Legumain Gene ORF cDNA clone expression plasmid, N-Flag tag - HG12846-NF from Sino Biological Species Human

Human Legumain Gene ORF cDNA clone expression plasmid, N-HA tag - HG12846-NY from Sino Biological Species Human

Human Legumain Gene ORF cDNA clone expression plasmid, N-Myc tag - HG12846-NM from Sino Biological Species Human

Human Legumain Gene ORF cDNA clone expression plasmid, C-Flag tag - HG12846-CF from Sino Biological Species Human

Human Legumain Gene ORF cDNA clone expression plasmid, N-His tag - HG12846-NH from Sino Biological Species Human

Human Legumain Gene ORF cDNA clone expression plasmid, C-Myc tag - HG12846-CM from Sino Biological Species Human

Human Legumain Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG12846-ACR from Sino Biological Species Human

Human Legumain Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG12846-ANR from Sino Biological Species Human

Human Legumain Gene ORF cDNA clone expression plasmid - HG12846-UT from Sino Biological Species Human

Human Legumain Gene ORF cDNA clone expression plasmid, C-His tag - HG12846-CH from Sino Biological Species Human

Human Legumain Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG12846-ANG from Sino Biological Species Human

Human LGMN ORF Clone (BC003061) - CDCS406370 from Creative biogene Species Human Accession Q99538

Human LGMN ORF clone (BC003061) - CDCB159020 from Creative biogene Species Human

Human LGMN Gene cDNA Clone - orb144069 from Biorbyt Prices $264.00 Sizes 10 μg Species Human

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