LGMN

Gene Symbol	LGMN
Entrez Gene	5641
Alt Symbol	AEP, LGMN1, PRSC1
Species	Human
Gene Type	protein-coding
Description	legumain
Other Description	asparaginyl endopeptidase|cysteine protease 1|protease, cysteine 1|protease, cysteine, 1 (legumain)
Swissprots	O00123 Q86TV3 Q99538 Q9BTY1 Q86TV2
Accessions	CAS91767 CAS91768 CAS91772 EAW81500 EAW81501 Q99538 AK225822 AK291534 BAF84223 AK291560 BAF84249 AK297074 BAH12490 AK297780 BAH12664 BC003061 AAH03061 BC013678 AAH13678 BM838821 BX161380 CAD61872 BX161422 CAD61895 BX161434 CAD61906 CD366588 CR457406 CAG33687 D55696 BAA09530 DA347449 DQ891884 ABM82810 DQ895070 ABM85996 DQ895071 ABM85997 EU176651 ABW03452 Y09862 CAA70989 XM_005267862 XP_005267919 XM_005267863 XP_005267920 XM_011536970 XP_011535272 NM_001008530 NP_001008530 NM_005606 NP_005597
Function	Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation (By similarity). May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system. {ECO:0000250, ECO:0000269|PubMed:23776206}.
Subcellular Location	Lysosome {ECO:0000250}.
Tissue Specificity	Ubiquitous. Particularly abundant in kidney, heart and placenta.
Top Pathways	Lysosome, Antigen processing and presentation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human LGMN / Legumain ELISA Kit (Sandwich ELISA) - LS-F6730 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.123 ng/ml Range 0.313-20 ng/ml

Human LGMN / Legumain ELISA Kit (Custom ELISA) - LS-F357 from LifeSpan Bioscience Category ELISA Kit Prices $670.00, $1,190.00, $2,570.00 Sizes 1 plate, 2 plate, 5 plate Sensitivity To be determined Range 0.313-20 ng/ml

Mouse LGMN / Legumain ELISA Kit (Sandwich ELISA) - LS-F8653 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 0.055 ng/ml Range 0.313-20 ng/ml

Human LGMN / Legumain ELISA Kit (Sandwich ELISA) - LS-F11947 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 ng/ml Range 0.313-20 ng/ml

Human LGMN / Legumain ELISA Kit - RAB0708 from Sigma-Aldrich Category ELISA Kit Prices $633.00 Sizes 1 kt

Human Total Legumain DuoSet ELISA - DY4769 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 31.20 - 2,000 pg/mL

Human Pro-Legumain DuoSet ELISA - DY2199 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 31.20 - 2,000 pg/mL

Human Legumain ELISA Kit - abx152188 from Abbexa Category ELISA Kit Sensitivity 0.118 ng/ml Range 0.313 ng/ml - 20 ng/ml

Alpha-Endorphin (aEP), Human, ELISA Kit - CEA714Hu from ARP American Research Products Category ELISA Kit Prices $650.00 Sizes 96 t Sensitivity 4.45pg/mL Range 12.35-1,000pg/mL

Legumain (LGMN), Human, ELISA Kit - CSB-EL012903HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 1.95 pg/ml Range 7.8 pg/ml-500 pg/ml

Legumain (LGMN), Human, ELISA Kit - SEC564Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.118ng/mL Range 0.312-20ng/mL

Legumain, LGMN, Human, ELISA Kit - E1201h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.156-10 ng/mL

LGMN (Human) IP-WB Antibody Pair - H00005641-PW1 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

LGMN (Human) IP-WB Antibody Pair - H00005641-PW2 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

LGMN (Human) Matched Antibody Pair - H00005641-AP11 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

Custom Human Legumain ELISA - ELH-Legumain from RayBiotech Category ELISA Kit Prices $615.00, $1,107.00, $2,460.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

Legumain, ELISA Kit - MBS098840 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Legumain, ELISA Kit - MBS060467 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

legumain, ELISA Kit - MBS931900 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human LGMN is typically less than 1.95 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 7.8 pg/ml -500 pg/ml.

Legumain, ELISA Kit - MBS081063 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Legumain, ELISA Kit - MBS061886 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Legumain, ELISA Kit - MBS081350 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Legumain, ELISA Kit - MBS056284 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Legumain, ELISA Kit - MBS091615 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Legumain (LGMN), ELISA Kit - MBS2020749 from MyBioSource Category ELISA Kit Prices $385.00, $575.00, $785.00, $3,210.00, $5,825.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.055ng/mL. Range 0.156-10ng/mL

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