| Gene Symbol |
PPP1R15A
|
| Entrez Gene |
23645
|
| Alt Symbol |
GADD34
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
protein phosphatase 1, regulatory subunit 15A
|
| Other Description |
growth arrest and DNA damage-inducible protein GADD34|growth arrest and DNA-damage-inducible 34|myeloid differentiation primary response protein MyD116 homolog|protein phosphatase 1 regulatory subunit 15A|protein phosphatase 1, regulatory (inhibitor) subunit 15A
|
| Swissprots |
O75807 Q9NVU6 Q6IA96 B4DKQ3
|
| Accessions |
CBX47609 EAW52409 O75807 AK001361 BAA91649 AK225632 AK296668 BAG59265 AK297615 BAG59994 AK298765 BAG60907 AK311366 BC003067 AAH03067 CR457259 CAG33540 DA484808 DQ891855 ABM82781 EU176641 ABW03442 U83981 AAC25631 NM_014330 NP_055145
|
| Function |
Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on 'Ser-15'. {ECO:0000269|PubMed:11564868, ECO:0000269|PubMed:12556489, ECO:0000269|PubMed:14635196, ECO:0000269|PubMed:14718519, ECO:0000269|PubMed:8139541}.
|
| Subcellular Location |
Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side {ECO:0000269|PubMed:12556489, ECO:0000269|PubMed:21518769}. Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side {ECO:0000269|PubMed:21518769}. Note=Associates with membranes via an N-terminal amphipathic intramembrane region. {ECO:0000269|PubMed:21518769}.
|
| Top Pathways |
Protein processing in endoplasmic reticulum
|
![Western Blot: GADD34 Overexpression Lysate (Adult Normal) [NBL1-14676] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for GADD34.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/928_GADD34%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-14676-img0002.jpg)