PPP1R15A

Gene Symbol	PPP1R15A
Entrez Gene	23645
Alt Symbol	GADD34
Species	Human
Gene Type	protein-coding
Description	protein phosphatase 1, regulatory subunit 15A
Other Description	growth arrest and DNA damage-inducible protein GADD34|growth arrest and DNA-damage-inducible 34|myeloid differentiation primary response protein MyD116 homolog|protein phosphatase 1 regulatory subunit 15A|protein phosphatase 1, regulatory (inhibitor) subunit 15A
Swissprots	O75807 Q9NVU6 Q6IA96 B4DKQ3
Accessions	CBX47609 EAW52409 O75807 AK001361 BAA91649 AK225632 AK296668 BAG59265 AK297615 BAG59994 AK298765 BAG60907 AK311366 BC003067 AAH03067 CR457259 CAG33540 DA484808 DQ891855 ABM82781 EU176641 ABW03442 U83981 AAC25631 NM_014330 NP_055145
Function	Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on 'Ser-15'. {ECO:0000269|PubMed:11564868, ECO:0000269|PubMed:12556489, ECO:0000269|PubMed:14635196, ECO:0000269|PubMed:14718519, ECO:0000269|PubMed:8139541}.
Subcellular Location	Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side {ECO:0000269|PubMed:12556489, ECO:0000269|PubMed:21518769}. Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side {ECO:0000269|PubMed:21518769}. Note=Associates with membranes via an N-terminal amphipathic intramembrane region. {ECO:0000269|PubMed:21518769}.
Top Pathways	Protein processing in endoplasmic reticulum

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PPP1R15A - MBS1270486 from MyBioSource Species Human Accession BC003067

Human PPP1R15A Gene cDNA clone plasmid - HG16601-U from Sino Biological Species Human

Human PPP1R15A Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG16601-ACG from Sino Biological Species Human

Human PPP1R15A Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG16601-ACR from Sino Biological Species Human

Human PPP1R15A Gene ORF cDNA clone expression plasmid, C-Flag tag - HG16601-CF from Sino Biological Species Human

Human PPP1R15A Gene ORF cDNA clone expression plasmid - HG12418-UT from Sino Biological Species Human

Human PPP1R15A Gene ORF cDNA clone expression plasmid, C-His tag - HG16601-CH from Sino Biological Species Human

Human PPP1R15A Gene ORF cDNA clone expression plasmid, C-Myc tag - HG16601-CM from Sino Biological Species Human

Human PPP1R15A Gene ORF cDNA clone expression plasmid, C-HA tag - HG16601-CY from Sino Biological Species Human

Human PPP1R15A Gene ORF cDNA clone expression plasmid, N-Flag tag - HG16601-NF from Sino Biological Species Human

Human PPP1R15A Gene ORF cDNA clone expression plasmid, N-His tag - HG16601-NH from Sino Biological Species Human

Human PPP1R15A Gene ORF cDNA clone expression plasmid, N-Myc tag - HG16601-NM from Sino Biological Species Human

Human PPP1R15A Gene ORF cDNA clone expression plasmid, N-HA tag - HG16601-NY from Sino Biological Species Human

Human PPP1R15A Gene ORF cDNA clone expression plasmid - HG16601-UT from Sino Biological Species Human

human PPP1R15A ORF clone (NM_014330.3) - CDCH066834 from Creative biogene Species Human

Human PPP1R15A ORF Clone (BC003067) - CDCS413580 from Creative biogene Species Human Accession O75807

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