PPP1R15A

Gene Symbol PPP1R15A
Entrez Gene 23645
Alt Symbol GADD34
Species Human
Gene Type protein-coding
Description protein phosphatase 1, regulatory subunit 15A
Other Description growth arrest and DNA damage-inducible protein GADD34|growth arrest and DNA-damage-inducible 34|myeloid differentiation primary response protein MyD116 homolog|protein phosphatase 1 regulatory subunit 15A|protein phosphatase 1, regulatory (inhibitor) subunit 15A
Swissprots O75807 Q9NVU6 Q6IA96 B4DKQ3
Accessions CBX47609 EAW52409 O75807 AK001361 BAA91649 AK225632 AK296668 BAG59265 AK297615 BAG59994 AK298765 BAG60907 AK311366 BC003067 AAH03067 CR457259 CAG33540 DA484808 DQ891855 ABM82781 EU176641 ABW03442 U83981 AAC25631 NM_014330 NP_055145
Function Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on 'Ser-15'. {ECO:0000269|PubMed:11564868, ECO:0000269|PubMed:12556489, ECO:0000269|PubMed:14635196, ECO:0000269|PubMed:14718519, ECO:0000269|PubMed:8139541}.
Subcellular Location Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side {ECO:0000269|PubMed:12556489, ECO:0000269|PubMed:21518769}. Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side {ECO:0000269|PubMed:21518769}. Note=Associates with membranes via an N-terminal amphipathic intramembrane region. {ECO:0000269|PubMed:21518769}.
Top Pathways Protein processing in endoplasmic reticulum

GADD 34 CRISPR/Cas9 KO Plasmid (h) - sc-400595 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

GADD 34 HDR Plasmid (h) - sc-400595-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GADD 34 Double Nickase Plasmid (h) - sc-400595-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GADD 34 Double Nickase Plasmid (h2) - sc-400595-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GADD 34 CRISPR Activation Plasmid (h) - sc-400595-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

GADD 34 CRISPR Activation Plasmid (h2) - sc-400595-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

GADD 34 Lentiviral Activation Particles (h) - sc-400595-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GADD 34 Lentiviral Activation Particles (h2) - sc-400595-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GADD 34 siRNA (h) - sc-37414 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

GADD 34 shRNA Plasmid (h) - sc-37414-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

GADD 34 shRNA (h) Lentiviral Particles - sc-37414-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU120481 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

MISSION® Human Phosphatase - SIHP0555 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 250 pmol

MISSION® Human Phosphatase - SIHP0553 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 250 pmol

MISSION® Human Phosphatase - SIHP0554 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 250 pmol

CompoZr® Knockout ZFN Kit - CKOZFN17268 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17268 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

PPP1R15A siRNA (Human) - CRH8419 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human PPP1R15A (NM_014330.3) - SHH381112 from Creative biogene

Category siRNA
Species Reactivities Human

Human PPP1R15A siRNA - orb268921 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

PPP1R15A shRNA Plasmid (Human) - CHH8419 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

PPP1R15A miRNA 3'UTR clone - MiUTR1H-08179 from Creative biogene

Species Reactivities Human
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