PPP1R15A

Gene Symbol	PPP1R15A
Entrez Gene	23645
Alt Symbol	GADD34
Species	Human
Gene Type	protein-coding
Description	protein phosphatase 1, regulatory subunit 15A
Other Description	growth arrest and DNA damage-inducible protein GADD34|growth arrest and DNA-damage-inducible 34|myeloid differentiation primary response protein MyD116 homolog|protein phosphatase 1 regulatory subunit 15A|protein phosphatase 1, regulatory (inhibitor) subunit 15A
Swissprots	O75807 Q9NVU6 Q6IA96 B4DKQ3
Accessions	CBX47609 EAW52409 O75807 AK001361 BAA91649 AK225632 AK296668 BAG59265 AK297615 BAG59994 AK298765 BAG60907 AK311366 BC003067 AAH03067 CR457259 CAG33540 DA484808 DQ891855 ABM82781 EU176641 ABW03442 U83981 AAC25631 NM_014330 NP_055145
Function	Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on 'Ser-15'. {ECO:0000269|PubMed:11564868, ECO:0000269|PubMed:12556489, ECO:0000269|PubMed:14635196, ECO:0000269|PubMed:14718519, ECO:0000269|PubMed:8139541}.
Subcellular Location	Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side {ECO:0000269|PubMed:12556489, ECO:0000269|PubMed:21518769}. Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side {ECO:0000269|PubMed:21518769}. Note=Associates with membranes via an N-terminal amphipathic intramembrane region. {ECO:0000269|PubMed:21518769}.
Top Pathways	Protein processing in endoplasmic reticulum

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human GADD34 peptide - ab23166 from Abcam Category Peptide Species Human

Human GADD34 protein fragment - ab153242 from Abcam Category Protein Source Wheat germ Species Human

PPP1R15A / GADD34 Antibody Blocking Peptide - LS-E25201 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human GADD34 Protein - H00023645-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

GADD34 Peptide - NBP2-11494PEP from Novus Biologicals Category Peptide Prices $279.00 Sizes 250 µg

GADD34 blocking peptide - GTX74479-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

GADD34 Peptide - AC21-0022-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

GADD34 / PPP1R15A - H00023645-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

GADD34 / PPP1R15A - H00023645-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

GADD34 Peptide - 45-649P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse

GADD34 fusion protein - ag19287 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

GADD34 fusion protein - Ag0578 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human PPP1R15A protein, MYC/DDK-tagged - PPP1R15A-2943H from Creative Biomart Category Protein Source HEK293 Species Human

Recombinant Human Protein phosphatase 1 regulatory subunit 15A(PPP1R15A) - CSB-YP018528HU CSB-EP018528HU CSB-BP018528HU CSB-MP018528HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

GADD34 Protein - abx164940 from Abbexa Category Protein Species Human, Mouse, Rat

GADD34 / PPP1R15A - TP300581 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

PPP1R15A/GADD34, Peptide - MBS426414 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human

Recombinant Protein Phosphatase 1, Regulatory Subunit 15A (PPP1R15A) - RPC199Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Protein Phosphatase 1, Regulatory Subunit 15A (PPP1R15A) - RPC199Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

GADD34 Recombinant Protein Antigen - NBP1-89800PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

PPP1R15A Peptide, Human - M34GP12240H from Creative Peptides Category Peptide Source Synthetic. Species Human

PPP1R15A Recombinant Protein (OPCA03491) - OPCA03491 from Aviva Systems Biology Category Protein Prices $365.00 Sizes 50 µg Source Human

GADD34 Blocking Peptide - CBP7531 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human

PPP1R15A Immunizing peptide - orb16800 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg

Recombinant Human Protein phosphatase 1 regulatory subunit 15A(PPP1R15A),partial - AP74379 from Signalway Antibody Category Protein Prices $155.00, $390.00, $665.00, $1,090.00, $1,835.00, $2,915.00 Sizes 10 µg, 50 µg, 100 µg, 200 µg, 500 µg, 1 mg Source Yeast Species Human

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