PPIF

Gene Symbol PPIF
Entrez Gene 10105
Alt Symbol CYP3, CyP-M, Cyp-D, CypD
Species Human
Gene Type protein-coding
Description peptidylprolyl isomerase F
Other Description PPIase F|cyclophilin 3|cyclophilin D|cyclophilin F|mitochondrial cyclophilin|peptidyl-prolyl cis-trans isomerase F, mitochondrial|peptidyl-prolyl cis-trans isomerase, mitochondrial|rotamase F
Swissprots Q5W131 Q2YDB7 P30405
Accessions EAW54645 EAW54646 EAW54647 EAW54648 P30405 AK296669 BAG59266 AK312757 BAG35623 AL832720 AY358854 AAQ89213 BC005020 AAH05020 BC013204 BC110299 AAI10300 BE791220 EU831447 ACE87134 HQ447889 ADQ32373 M80254 AAA58434 XM_005269379 XP_005269436 NM_005729 NP_005720
Function PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial TP53 is involved in activating oxidative stress- induced necrosis. Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels. Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis. {ECO:0000269|PubMed:19228691, ECO:0000269|PubMed:22726440}.
Subcellular Location Mitochondrion matrix {ECO:0000269|PubMed:10406942}.
Top Pathways Huntington's disease, Calcium signaling pathway, Toxoplasmosis, cGMP-PKG signaling pathway

Cyclophilin F (C-12) - sc-82570 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Cyclophilin F (C-12): sc-82570. Western blot analysis of Cyclophilin F expression in Hep G2 whole cell lysate (A) and human platelet extract (B).

Cyclophilin F (E-15) - sc-82571 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Cyclophilin F (E-15): sc-82571. Western blot analysis of Cyclophilin F expression in HeLa (A), K-562 (B) and Ramos (C) whole cell lysates.

Cyclophilin F (G-9) - sc-376061 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Cyclophilin F (G-9): sc-376061. Western blot analysis of Cyclophilin F expression in Hep G2 (A) and PC-3 (B) whole cell lysates.

Cyclophilin F (H-40) - sc-368365 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Cyclophilin F (S-14) - sc-82573 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Cyclophilin F (S-14): sc-82573. Western blot analysis of Cyclophilin F expression in HeLa (A), K-562 (B) and Caco-2 (C) whole cell lysates.

Anti-Cyclophilin F antibody - ab64935 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab64935, at a 1/50 dilution, staining Human Cyclophilin F in paraffin-embedded brain tissue, by Immunohistochemistry, with (+) or without (-) immunising peptide.

Anti-Cyclophilin F antibody - ab3567 from Abcam

Host Rabbit
Clonality Polyclonal
Anti-Cyclophilin F antibody (ab3567) at 1 µg/ml + Rat heart lysateObserved band size : 15 kDa (why is the actual band size different from the predicted?)Anti-rabbit HRP (ab6721)

Anti-Cyclophilin F antibody - ab126573 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab126573 stained A431 cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab126573, 5µg/ml) overnight at +4°C. The secondary antibody (green) was ab96899, DyLight® 488 goat anti-rabbit IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-Cyclophilin F antibody - ab124149 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-Cyclophilin F antibody (ab124149) at 1/100 dilution + HepG2 cell line lysate at 35 µg

Anti-Cyclophilin F antibody [AT1F5] - ab86425 from Abcam

Prices $378.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone AT1F5
All lanes : Anti-Cyclophilin F antibody [AT1F5] (ab86425) at 1/500 dilutionLane 1 : 293T cell lysateLane 2 : HeLa cell lysateLysates/proteins at 20 µg per lane.SecondaryGoat anti-mouse secondary antibody conjugated to HRP developed using the ECL technique

Anti-Cyclophilin F antibody [EPR11311(B)] - ab155979 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR11311(B)
All lanes : Anti-Cyclophilin F antibody [EPR11311(B)] (ab155979) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : HepG2 cell lysateLane 3 : 293T cell lysateLane 4 : K562 cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labeled goat anti-rabbit IgG at 1/2000 dilution

Anti-Cyclophilin F antibody - Azide free - ab37664 from Abcam

Prices $376.00
Sizes 50 µg
Host Chicken
Clonality Polyclonal
Direct Elisa Test. Protein as test antigen. ab37664 as primary antibody and Goat anti-IgY HRP as 2nd antibody. Fixed amount of antibody (1 ug/ml) and serial dilutions of antigen.

Anti-PPIF / Cyclophilin F Antibody (aa102-131, AP) - LS-C284694 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PPIF / Cyclophilin F Antibody (aa102-131, APC) - LS-C284696 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PPIF / Cyclophilin F Antibody (Tyr121) - LS-C191963 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PPIF / Cyclophilin F Antibody (aa102-131, Biotin) - LS-C284697 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PPIF / Cyclophilin F Antibody (aa102-131, FITC) - LS-C284699 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PPIF / Cyclophilin F Antibody (aa102-131, PE) - LS-C284701 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PPIF / Cyclophilin F Antibody (aa102-131, Azide-free, HRP) - LS-C284700 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PPIF / Cyclophilin F Antibody (aa44-192, Biotin) - LS-C298219 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PPIF / Cyclophilin F Antibody (aa45-196, FITC) - LS-C303887 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PPIF / Cyclophilin F Antibody (aa45-196, Biotin) - LS-C299532 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PPIF / Cyclophilin F Antibody (aa44-192, FITC) - LS-C303896 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PPIF / Cyclophilin F Antibody (aa102-131) - LS-C324217 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PPIF / Cyclophilin F Antibody (aa92-141) - LS-C80839 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Transfected 293T cell lysate. Antibody concentration: 5.0 ug/ml. Gel concentration: 12%.
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