PPIF

Gene Symbol	PPIF
Entrez Gene	10105
Alt Symbol	CYP3, CyP-M, Cyp-D, CypD
Species	Human
Gene Type	protein-coding
Description	peptidylprolyl isomerase F
Other Description	PPIase F|cyclophilin 3|cyclophilin D|cyclophilin F|mitochondrial cyclophilin|peptidyl-prolyl cis-trans isomerase F, mitochondrial|peptidyl-prolyl cis-trans isomerase, mitochondrial|rotamase F
Swissprots	Q5W131 Q2YDB7 P30405
Accessions	EAW54645 EAW54646 EAW54647 EAW54648 P30405 AK296669 BAG59266 AK312757 BAG35623 AL832720 AY358854 AAQ89213 BC005020 AAH05020 BC013204 BC110299 AAI10300 BE791220 EU831447 ACE87134 HQ447889 ADQ32373 M80254 AAA58434 XM_005269379 XP_005269436 NM_005729 NP_005720
Function	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial TP53 is involved in activating oxidative stress- induced necrosis. Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels. Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis. {ECO:0000269|PubMed:19228691, ECO:0000269|PubMed:22726440}.
Subcellular Location	Mitochondrion matrix {ECO:0000269|PubMed:10406942}.
Top Pathways	Huntington's disease, Calcium signaling pathway, Toxoplasmosis, cGMP-PKG signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human-PPIF-cDNA-Clone - DC01589 from Abgent, a WuXi AppTec company Prices $279.45 Sizes 10 µg Species Human Accession BC005020

PPIF - MBS1270184 from MyBioSource Species Human Accession BC005020

Human PPIF cDNA clone(NM_005729.3) - CDFH014844 from Creative Biomart

Human PPIF ORF Clone(NM_005729.3) - CDCR291136 from Creative Biomart Species Human Accession NM_005729.3

Human PPIF ORF Clone(NM_005729.3) - CDCR291137 from Creative Biomart Species Human Accession NM_005729.3

Human PPIF ORF Clone(NM_005729.3) - CDCR291188 from Creative Biomart Species Human Accession NM_005729.3

Human PPIF/Cyclophilin F Gene ORF cDNA clone in cloning vector - HG14689-G from Sino Biological Species Human

Human PPIF/Cyclophilin F Gene ORF cDNA clone expression plasmid, N-Flag tag - HG14689-NF from Sino Biological Species Human

Human PPIF/Cyclophilin F Gene ORF cDNA clone expression plasmid, N-His tag - HG14689-NH from Sino Biological Species Human

Human PPIF/Cyclophilin F Gene ORF cDNA clone expression plasmid, N-HA tag - HG14689-NY from Sino Biological Species Human

Human PPIF/Cyclophilin F Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG14689-ACG from Sino Biological Species Human

Human PPIF/Cyclophilin F Gene ORF cDNA clone expression plasmid, C-Flag tag - HG14689-CF from Sino Biological Species Human

Human PPIF/Cyclophilin F Gene ORF cDNA clone expression plasmid, C-His tag - HG14689-CH from Sino Biological Species Human

Human PPIF/Cyclophilin F Gene ORF cDNA clone expression plasmid, N-Myc tag - HG14689-NM from Sino Biological Species Human

Human PPIF/Cyclophilin F Gene ORF cDNA clone expression plasmid, C-Myc tag - HG14689-CM from Sino Biological Species Human

Human PPIF/Cyclophilin F Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG14689-ACR from Sino Biological Species Human

Human PPIF/Cyclophilin F Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG14689-ANR from Sino Biological Species Human

Human PPIF/Cyclophilin F Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG14689-ANG from Sino Biological Species Human

Human PPIF/Cyclophilin F Gene ORF cDNA clone expression plasmid - HG14689-UT from Sino Biological Species Human

Human PPIF/Cyclophilin F Gene ORF cDNA clone expression plasmid, C-HA tag - HG14689-CY from Sino Biological Species Human

Human PPIF ORF Clone(NM_005729.3) - CDCR291136 from Creative biogene Species Human

Human PPIF ORF Clone (BC005020) - CDCS412394 from Creative biogene Species Human Accession P30405

Human PPIF ORF clone (BC005020) - CDCB158896 from Creative biogene Species Human

Human PPIF cDNA Clone(NM_005729.3) - CDFH014844 from Creative biogene Species Human

Human PPIF Gene cDNA Clone - orb144817 from Biorbyt Prices $264.00 Sizes 10 μg Species Human

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