| Gene Symbol | PPIF |
|---|---|
| Entrez Gene | 10105 |
| Alt Symbol | CYP3, CyP-M, Cyp-D, CypD |
| Species | Human |
| Gene Type | protein-coding |
| Description | peptidylprolyl isomerase F |
| Other Description | PPIase F|cyclophilin 3|cyclophilin D|cyclophilin F|mitochondrial cyclophilin|peptidyl-prolyl cis-trans isomerase F, mitochondrial|peptidyl-prolyl cis-trans isomerase, mitochondrial|rotamase F |
| Swissprots | Q5W131 Q2YDB7 P30405 |
| Accessions | EAW54645 EAW54646 EAW54647 EAW54648 P30405 AK296669 BAG59266 AK312757 BAG35623 AL832720 AY358854 AAQ89213 BC005020 AAH05020 BC013204 BC110299 AAI10300 BE791220 EU831447 ACE87134 HQ447889 ADQ32373 M80254 AAA58434 XM_005269379 XP_005269436 NM_005729 NP_005720 |
| Function | PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial TP53 is involved in activating oxidative stress- induced necrosis. Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels. Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis. {ECO:0000269|PubMed:19228691, ECO:0000269|PubMed:22726440}. |
| Subcellular Location | Mitochondrion matrix {ECO:0000269|PubMed:10406942}. |
| Top Pathways | Huntington's disease, Calcium signaling pathway, Toxoplasmosis, cGMP-PKG signaling pathway |
Cyclophilin F CRISPR/Cas9 KO Plasmid (h) - sc-402902 from Santa Cruz Biotechnology
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Cyclophilin F HDR Plasmid (h) - sc-402902-HDR from Santa Cruz Biotechnology
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Cyclophilin F Double Nickase Plasmid (h) - sc-402902-NIC from Santa Cruz Biotechnology
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Cyclophilin F Double Nickase Plasmid (h2) - sc-402902-NIC-2 from Santa Cruz Biotechnology
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Cyclophilin F CRISPR Activation Plasmid (h) - sc-402902-ACT from Santa Cruz Biotechnology
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Cyclophilin F CRISPR Activation Plasmid (h2) - sc-402902-ACT-2 from Santa Cruz Biotechnology
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Cyclophilin F Lentiviral Activation Particles (h) - sc-402902-LAC from Santa Cruz Biotechnology
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Cyclophilin F Lentiviral Activation Particles (h2) - sc-402902-LAC-2 from Santa Cruz Biotechnology
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Cyclophilin F siRNA (h) - sc-77071 from Santa Cruz Biotechnology
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Cyclophilin F shRNA Plasmid (h) - sc-77071-SH from Santa Cruz Biotechnology
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Cyclophilin F shRNA (h) Lentiviral Particles - sc-77071-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU144421 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2307 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2307 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09589 from Sigma-Aldrich
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PPIF siRNA (Human) - CRH6812 from Cohesion Biosciences
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Cyclophilin-F RNAi - H00010105-R01 from Novus Biologicals
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shRNA set against Human PPIF (NM_005729.3) - SHH380656 from Creative biogene
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shRNA set against Human PPIF(NM_005729.3) - SHR132090 from Creative biogene
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Human PPIF siRNA - orb267314 from Biorbyt
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PPIF shRNA Plasmid (Human) - CHH6812 from Cohesion Biosciences
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PPIF miRNA 3'UTR clone - MiUTR1H-08154 from Creative biogene
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