| Gene Symbol |
PPIF
|
| Entrez Gene |
10105
|
| Alt Symbol |
CYP3, CyP-M, Cyp-D, CypD
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
peptidylprolyl isomerase F
|
| Other Description |
PPIase F|cyclophilin 3|cyclophilin D|cyclophilin F|mitochondrial cyclophilin|peptidyl-prolyl cis-trans isomerase F, mitochondrial|peptidyl-prolyl cis-trans isomerase, mitochondrial|rotamase F
|
| Swissprots |
Q5W131 Q2YDB7 P30405
|
| Accessions |
EAW54645 EAW54646 EAW54647 EAW54648 P30405 AK296669 BAG59266 AK312757 BAG35623 AL832720 AY358854 AAQ89213 BC005020 AAH05020 BC013204 BC110299 AAI10300 BE791220 EU831447 ACE87134 HQ447889 ADQ32373 M80254 AAA58434 XM_005269379 XP_005269436 NM_005729 NP_005720
|
| Function |
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial TP53 is involved in activating oxidative stress- induced necrosis. Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels. Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis. {ECO:0000269|PubMed:19228691, ECO:0000269|PubMed:22726440}.
|
| Subcellular Location |
Mitochondrion matrix {ECO:0000269|PubMed:10406942}.
|
| Top Pathways |
Huntington's disease, Calcium signaling pathway, Toxoplasmosis, cGMP-PKG signaling pathway
|
