PPIF

Gene Symbol	PPIF
Entrez Gene	10105
Alt Symbol	CYP3, CyP-M, Cyp-D, CypD
Species	Human
Gene Type	protein-coding
Description	peptidylprolyl isomerase F
Other Description	PPIase F|cyclophilin 3|cyclophilin D|cyclophilin F|mitochondrial cyclophilin|peptidyl-prolyl cis-trans isomerase F, mitochondrial|peptidyl-prolyl cis-trans isomerase, mitochondrial|rotamase F
Swissprots	Q5W131 Q2YDB7 P30405
Accessions	EAW54645 EAW54646 EAW54647 EAW54648 P30405 AK296669 BAG59266 AK312757 BAG35623 AL832720 AY358854 AAQ89213 BC005020 AAH05020 BC013204 BC110299 AAI10300 BE791220 EU831447 ACE87134 HQ447889 ADQ32373 M80254 AAA58434 XM_005269379 XP_005269436 NM_005729 NP_005720
Function	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial TP53 is involved in activating oxidative stress- induced necrosis. Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels. Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis. {ECO:0000269|PubMed:19228691, ECO:0000269|PubMed:22726440}.
Subcellular Location	Mitochondrion matrix {ECO:0000269|PubMed:10406942}.
Top Pathways	Huntington's disease, Calcium signaling pathway, Toxoplasmosis, cGMP-PKG signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Cyclophilin F full length protein - ab79186 from Abcam Category Protein Prices $192.00, $588.00 Sizes 100 µg, 500 µg Source E. coli Species Human

Cyclophilin F peptide - ab5017 from Abcam Category Peptide Prices $181.00 Sizes 50 µg

Human Cyclophilin F full length protein - ab188452 from Abcam Category Protein Source E. coli Species Human

Human Cyclophilin F full length protein - ab40517 from Abcam Category Protein Source E. coli Species Human

Human Cyclophilin F full length protein - ab169897 from Abcam Category Protein Source E. coli Species Human

Rat Cyclophilin F full length protein - ab201871 from Abcam Category Protein Source E. coli Species Rat

CYP-M / CYP20A1 Antibody Blocking Peptide - LS-E1823 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CYP-M / CYP20A1 Antibody Blocking Peptide - LS-E8970 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CYP-M / CYP20A1 Antibody Blocking Peptide - LS-E21099 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PPIF / Cyclophilin F Antibody Blocking Peptide - LS-E4094 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Cyclophilin-F Protein - NBC1-18533 from Novus Biologicals Category Protein Prices $229.00 Sizes 100 µg Species Human

Cyclophilin-F Partial Recombinant Protein - H00010105-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Cyclophilin-F Recombinant Protein - H00010105-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Species Human

Cyclophilin-F Recombinant Protein - P3472 from Novus Biologicals Category Protein Prices $449.00 Sizes 100 µg Species Human

PPIF-Antibody-Center-Blocking-Peptide - BP16334c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PPIF Protein (OPPA02002) - OPPA02002 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 10 µg Source E. Coli

Human PPIF protein - orb90234 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 10 μg, 50 μg Source E.coli Species Human

Human Cyclophilin F (His Tag) protein - orb232337 from Biorbyt Category Protein Prices $196.00, $357.00 Sizes 10 μg, 100 μg Species Human

PPIF Blocking Peptide - 33R-3589 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PPIF protein (His tag) - 80R-1084 from Fitzgerald Category Protein Prices $180.00 Sizes 100 µg Source E.coli

Cyclophilin F Blocking Peptide - abx063648 from Abbexa Category Peptide Species Human, Mouse, Rat, Rabbit

Human PPIF Protein - abx068460 from Abbexa Category Protein Source E.coli Species Human

Cyclophilin F (30-207, His-tag) - AR09070PU-L from Acris Antibodies Category Protein Prices $585.00 Sizes 500 µg Source E. coli Species Human

Cyclophilin F (30-207, His-tag) - AR09070PU-N from Acris Antibodies Category Protein Prices $270.00 Sizes 100 µg Source E. coli Species Human

Cyclophilin F - H00010105-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

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