| Gene Symbol | PPIF |
|---|---|
| Entrez Gene | 10105 |
| Alt Symbol | CYP3, CyP-M, Cyp-D, CypD |
| Species | Human |
| Gene Type | protein-coding |
| Description | peptidylprolyl isomerase F |
| Other Description | PPIase F|cyclophilin 3|cyclophilin D|cyclophilin F|mitochondrial cyclophilin|peptidyl-prolyl cis-trans isomerase F, mitochondrial|peptidyl-prolyl cis-trans isomerase, mitochondrial|rotamase F |
| Swissprots | Q5W131 Q2YDB7 P30405 |
| Accessions | EAW54645 EAW54646 EAW54647 EAW54648 P30405 AK296669 BAG59266 AK312757 BAG35623 AL832720 AY358854 AAQ89213 BC005020 AAH05020 BC013204 BC110299 AAI10300 BE791220 EU831447 ACE87134 HQ447889 ADQ32373 M80254 AAA58434 XM_005269379 XP_005269436 NM_005729 NP_005720 |
| Function | PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial TP53 is involved in activating oxidative stress- induced necrosis. Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels. Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis. {ECO:0000269|PubMed:19228691, ECO:0000269|PubMed:22726440}. |
| Subcellular Location | Mitochondrion matrix {ECO:0000269|PubMed:10406942}. |
| Top Pathways | Huntington's disease, Calcium signaling pathway, Toxoplasmosis, cGMP-PKG signaling pathway |
Mouse/Human/Rat PPIF / Cyclophilin F ELISA Kit (Cell-Based ELISA) - LS-F3084 from LifeSpan Bioscience
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Peptidyl-prolyl cis-trans isomerase F, mitochondrial (PPIF), Human, ELISA Kit - CSB-EL018476HU from ARP American Research Products
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peptidylprolyl isomerase F, ELISA Kit - MBS942202 from MyBioSource
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PPIF Colorimetric Cell-Based ELISA - CB5872 from Assay Biotechnology
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Human Peptidyl-prolyl cis-trans isomerase F, mitochondrial(PPIF) ELISA kit - CSB-EL018476HU from Cusabio
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PPIF ELISA Kit - DEIA-XYA1503 from Creative Diagnostics
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Human PPIF / Cyclophilin F ELISA Kit (Sandwich ELISA) - LS-F26771 from LifeSpan Bioscience
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Rat PPIF / Cyclophilin F ELISA Kit (Sandwich ELISA) - LS-F27392 from LifeSpan Bioscience
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Mouse PPIF / Cyclophilin F ELISA Kit (Competitive EIA) - LS-F28114 from LifeSpan Bioscience
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Human Peptidyl-prolyl cis-trans isomerase F, mitochondrial (PPIF) ELISA Kit - EKC34950 from Biomatik
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PPIF ELISA Kit - KSP-572 from Nordic BioSite
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Human PPIF ELISA Kit - E028612 from Biobool
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anti-Cyclophilin F antibody [1F5] - ARG56980 from Arigo Biolaboratories
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Human PPIF ELISA Kit - orb404992 from Biorbyt
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PPIF Colorimetric Cell-Based ELISA Kit - EKA50734 from Biomatik
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