| Gene Symbol |
BACE2
|
| Entrez Gene |
25825
|
| Alt Symbol |
AEPLC, ALP56, ASP1, ASP21, BAE2, CDA13, CEAP1, DRAP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
beta-site APP-cleaving enzyme 2
|
| Other Description |
56 kDa aspartic-like protease|Down syndrome region aspartic protease|aspartyl protease 1|beta-secretase 2|beta-site amyloid beta A4 precursor protein-cleaving enzyme 2|memapsin-1|membrane-associated aspartic protease 1|theta-secretase|transmembrane aspartic proteinase Asp1
|
| Swissprots |
Q8N2D4 A8K7P1 Q9NZL1 Q9Y5Z0 Q5DIH8 Q9H2V8 Q9NZL2 Q9UJT6
|
| Accessions |
AAX14808 AAZ05450 CAB90458 CAB90554 EAX09611 EAX09612 EAX09613 Q9Y5Z0 AF050171 AAD45963 AF117892 AAD45240 AF178532 AAF29494 AF188276 AAF35835 AF188277 AAF35836 AF200192 AAF13714 AF200342 AAF17078 AF204944 AAF26368 AF212252 AAG41783 AK023647 AK075539 BAC11682 AK292056 BAF84745 AY358927 AAQ89286 AY429520 AY429521 BC014453 AAH14453 BC020582 BQ006998 DQ895416 ABM86342 EU176330 ABW03781 NM_012105 NP_036237 NM_138991 NP_620476 NM_138992 NP_620477
|
| Function |
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C- terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. {ECO:0000269|PubMed:10591213, ECO:0000269|PubMed:11083922, ECO:0000269|PubMed:11423558, ECO:0000269|PubMed:15857888, ECO:0000269|PubMed:16816112}.
|
| Subcellular Location |
Membrane; Single-pass type I membrane protein. Golgi apparatus. Endoplasmic reticulum. Endosome. Cell surface.
|
| Tissue Specificity |
Brain. Present in neurons within the hippocampus, frontal cortex and temporal cortex (at protein level). Expressed at low levels in most peripheral tissues and at higher levels in colon, kidney, pancreas, placenta, prostate, stomach and trachea. Expressed at low levels in the brain. Found in spinal cord, medulla oblongata, substantia nigra and locus coruleus. Expressed in the ductal epithelium of both normal and malignant prostate. {ECO:0000269|PubMed:10591213, ECO:0000269|PubMed:10677483, ECO:0000269|PubMed:10683441, ECO:0000269|PubMed:10749877, ECO:0000269|PubMed:10838186, ECO:0000269|PubMed:10965118, ECO:0000269|PubMed:11083922}.
|
| Top Pathways |
Alzheimer's disease
|
