BACE2

Gene Symbol	BACE2
Entrez Gene	25825
Alt Symbol	AEPLC, ALP56, ASP1, ASP21, BAE2, CDA13, CEAP1, DRAP
Species	Human
Gene Type	protein-coding
Description	beta-site APP-cleaving enzyme 2
Other Description	56 kDa aspartic-like protease|Down syndrome region aspartic protease|aspartyl protease 1|beta-secretase 2|beta-site amyloid beta A4 precursor protein-cleaving enzyme 2|memapsin-1|membrane-associated aspartic protease 1|theta-secretase|transmembrane aspartic proteinase Asp1
Swissprots	Q8N2D4 A8K7P1 Q9NZL1 Q9Y5Z0 Q5DIH8 Q9H2V8 Q9NZL2 Q9UJT6
Accessions	AAX14808 AAZ05450 CAB90458 CAB90554 EAX09611 EAX09612 EAX09613 Q9Y5Z0 AF050171 AAD45963 AF117892 AAD45240 AF178532 AAF29494 AF188276 AAF35835 AF188277 AAF35836 AF200192 AAF13714 AF200342 AAF17078 AF204944 AAF26368 AF212252 AAG41783 AK023647 AK075539 BAC11682 AK292056 BAF84745 AY358927 AAQ89286 AY429520 AY429521 BC014453 AAH14453 BC020582 BQ006998 DQ895416 ABM86342 EU176330 ABW03781 NM_012105 NP_036237 NM_138991 NP_620476 NM_138992 NP_620477
Function	Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C- terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. {ECO:0000269|PubMed:10591213, ECO:0000269|PubMed:11083922, ECO:0000269|PubMed:11423558, ECO:0000269|PubMed:15857888, ECO:0000269|PubMed:16816112}.
Subcellular Location	Membrane; Single-pass type I membrane protein. Golgi apparatus. Endoplasmic reticulum. Endosome. Cell surface.
Tissue Specificity	Brain. Present in neurons within the hippocampus, frontal cortex and temporal cortex (at protein level). Expressed at low levels in most peripheral tissues and at higher levels in colon, kidney, pancreas, placenta, prostate, stomach and trachea. Expressed at low levels in the brain. Found in spinal cord, medulla oblongata, substantia nigra and locus coruleus. Expressed in the ductal epithelium of both normal and malignant prostate. {ECO:0000269|PubMed:10591213, ECO:0000269|PubMed:10677483, ECO:0000269|PubMed:10683441, ECO:0000269|PubMed:10749877, ECO:0000269|PubMed:10838186, ECO:0000269|PubMed:10965118, ECO:0000269|PubMed:11083922}.
Top Pathways	Alzheimer's disease

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ALP 56 Gene - orb91271 from Biorbyt Prices $255.00 Sizes 10 μg Species Human

Human BACE2 / Beta secretase 2 Gene ORF cDNA clone in cloning vector - HG10783-M from Sino Biological Species Human

Human BACE2 Gene cDNA Clone (full-length ORF Clone), expression ready, untagged - HG10783-M-N from Sino Biological Species Human Accession NM_012105.3

Human BACE2 / Beta secretase 2 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG10783-NF from Sino Biological Species Human

Human BACE2 / Beta secretase 2 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG10783-NM from Sino Biological Species Human

Human BACE2 / Beta secretase 2 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10783-CF from Sino Biological Species Human

Human BACE2 / Beta secretase 2 Gene ORF cDNA clone expression plasmid, C-HA tag - HG10783-CY from Sino Biological Species Human

Human BACE2 / Beta secretase 2 Gene ORF cDNA clone expression plasmid, N-His tag - HG10783-NH from Sino Biological Species Human

Human BACE2 / Beta secretase 2 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG10783-CM from Sino Biological Species Human

Human BACE2 / Beta secretase 2 Gene ORF cDNA clone expression plasmid, N-HA tag - HG10783-NY from Sino Biological Species Human

Human BACE2 / Beta secretase 2 Gene ORF cDNA clone expression plasmid, C-His tag - HG10783-CH from Sino Biological Species Human

Human BACE2 / Beta secretase 2 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG10783-ACR from Sino Biological Species Human

Human BACE2 / Beta secretase 2 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG10783-ACG from Sino Biological Species Human

Human BACE2 / Beta secretase 2 Gene ORF cDNA clone expression plasmid - HG10783-UT from Sino Biological Species Human

BACE2 - CL01202H01 from Elabscience Species Human Accession NM_012105.3

BACE2 - CL01202H02 from Elabscience Species Human Accession NM_138991.1

BACE2 - CL01202H03 from Elabscience Species Human Accession NM_138992.1

Human BACE2 ORF clone(NM_012105.3) - CDCL182802 from Creative biogene Species Human

Human BACE2 ORF clone (NM_138992.1) - CDCR032948 from Creative biogene Species Human

Human BACE2 cDNA Clone(NM_138991.1) - CDFG008327 from Creative biogene Species Human

Human BACE2 cDNA Clone(NM_138992.1) - CDFG008329 from Creative biogene Species Human

Human BACE2 cDNA Clone(NM_012105.3) - CDFH001610 from Creative biogene Species Human

Human BACE2 cDNA Clone(NM_012105.3) - CDFH001611 from Creative biogene Species Human

Human BACE2 cDNA Clone(NM_012105.3) - CDFH001612 from Creative biogene Species Human

Human BACE2 ORF clone (NM_138991.1) - CDCR032946 from Creative biogene Species Human

Search more