BACE2

Gene Symbol	BACE2
Entrez Gene	25825
Alt Symbol	AEPLC, ALP56, ASP1, ASP21, BAE2, CDA13, CEAP1, DRAP
Species	Human
Gene Type	protein-coding
Description	beta-site APP-cleaving enzyme 2
Other Description	56 kDa aspartic-like protease|Down syndrome region aspartic protease|aspartyl protease 1|beta-secretase 2|beta-site amyloid beta A4 precursor protein-cleaving enzyme 2|memapsin-1|membrane-associated aspartic protease 1|theta-secretase|transmembrane aspartic proteinase Asp1
Swissprots	Q8N2D4 A8K7P1 Q9NZL1 Q9Y5Z0 Q5DIH8 Q9H2V8 Q9NZL2 Q9UJT6
Accessions	AAX14808 AAZ05450 CAB90458 CAB90554 EAX09611 EAX09612 EAX09613 Q9Y5Z0 AF050171 AAD45963 AF117892 AAD45240 AF178532 AAF29494 AF188276 AAF35835 AF188277 AAF35836 AF200192 AAF13714 AF200342 AAF17078 AF204944 AAF26368 AF212252 AAG41783 AK023647 AK075539 BAC11682 AK292056 BAF84745 AY358927 AAQ89286 AY429520 AY429521 BC014453 AAH14453 BC020582 BQ006998 DQ895416 ABM86342 EU176330 ABW03781 NM_012105 NP_036237 NM_138991 NP_620476 NM_138992 NP_620477
Function	Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C- terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. {ECO:0000269|PubMed:10591213, ECO:0000269|PubMed:11083922, ECO:0000269|PubMed:11423558, ECO:0000269|PubMed:15857888, ECO:0000269|PubMed:16816112}.
Subcellular Location	Membrane; Single-pass type I membrane protein. Golgi apparatus. Endoplasmic reticulum. Endosome. Cell surface.
Tissue Specificity	Brain. Present in neurons within the hippocampus, frontal cortex and temporal cortex (at protein level). Expressed at low levels in most peripheral tissues and at higher levels in colon, kidney, pancreas, placenta, prostate, stomach and trachea. Expressed at low levels in the brain. Found in spinal cord, medulla oblongata, substantia nigra and locus coruleus. Expressed in the ductal epithelium of both normal and malignant prostate. {ECO:0000269|PubMed:10591213, ECO:0000269|PubMed:10677483, ECO:0000269|PubMed:10683441, ECO:0000269|PubMed:10749877, ECO:0000269|PubMed:10838186, ECO:0000269|PubMed:10965118, ECO:0000269|PubMed:11083922}.
Top Pathways	Alzheimer's disease

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active Sulfate adenylyltransferase full length protein - ab68650 from Abcam Category Protein Prices $432.00 Sizes 50 units Source E. coli

BACE2 peptide - ab41288 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

BACE2 peptide - ab41289 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

BACE2 peptide - ab41290 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

BACE2 peptide - ab5869 from Abcam Category Peptide Prices $181.00 Sizes 50 µg

BACE2 peptide - ab5873 from Abcam Category Peptide Prices $181.00 Sizes 50 µg

BACE2 peptide - ab8391 from Abcam Category Peptide Prices $181.00 Sizes 50 µg

BACE2 peptide - ab8392 from Abcam Category Peptide Prices $181.00 Sizes 50 µg

Human BACE2 protein fragment - ab153246 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

BACE2 Antibody Blocking Peptide - LS-E8077 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BACE2 Antibody Blocking Peptide - LS-E8082 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BACE2 Antibody Blocking Peptide - LS-E17042 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BACE2 Antibody Blocking Peptide - LS-E17043 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BACE2 Antibody Blocking Peptide - LS-E29927 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

BACE2 Antibody Blocking Peptide - LS-E29926 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

BACE-2 Partial Recombinant Protein - H00025825-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

BACE-2 Blocking Peptide - NBP1-77308PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

BACE-2 Blocking Peptide - NBP1-77309PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

BACE-2 Peptide - P1731 from Novus Biologicals Category Peptide Species Human

BACE-2 Peptide - P1717 from Novus Biologicals Category Peptide Species Human

BACE-2 Peptide - P1716 from Novus Biologicals Category Peptide Species Human

BACE2-Antibody-C-term-Blocking-peptide - BP13838b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

BACE2-Antibody-Center-Blocking-Peptide - BP6121a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

BACE2C-Antibody-C-term-Blocking-Peptide - BP6106a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

BACE2B-Antibody-C-term-Blocking-Peptide - BP6105a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

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