BACE2

Gene Symbol	BACE2
Entrez Gene	25825
Alt Symbol	AEPLC, ALP56, ASP1, ASP21, BAE2, CDA13, CEAP1, DRAP
Species	Human
Gene Type	protein-coding
Description	beta-site APP-cleaving enzyme 2
Other Description	56 kDa aspartic-like protease|Down syndrome region aspartic protease|aspartyl protease 1|beta-secretase 2|beta-site amyloid beta A4 precursor protein-cleaving enzyme 2|memapsin-1|membrane-associated aspartic protease 1|theta-secretase|transmembrane aspartic proteinase Asp1
Swissprots	Q8N2D4 A8K7P1 Q9NZL1 Q9Y5Z0 Q5DIH8 Q9H2V8 Q9NZL2 Q9UJT6
Accessions	AAX14808 AAZ05450 CAB90458 CAB90554 EAX09611 EAX09612 EAX09613 Q9Y5Z0 AF050171 AAD45963 AF117892 AAD45240 AF178532 AAF29494 AF188276 AAF35835 AF188277 AAF35836 AF200192 AAF13714 AF200342 AAF17078 AF204944 AAF26368 AF212252 AAG41783 AK023647 AK075539 BAC11682 AK292056 BAF84745 AY358927 AAQ89286 AY429520 AY429521 BC014453 AAH14453 BC020582 BQ006998 DQ895416 ABM86342 EU176330 ABW03781 NM_012105 NP_036237 NM_138991 NP_620476 NM_138992 NP_620477
Function	Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C- terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. {ECO:0000269|PubMed:10591213, ECO:0000269|PubMed:11083922, ECO:0000269|PubMed:11423558, ECO:0000269|PubMed:15857888, ECO:0000269|PubMed:16816112}.
Subcellular Location	Membrane; Single-pass type I membrane protein. Golgi apparatus. Endoplasmic reticulum. Endosome. Cell surface.
Tissue Specificity	Brain. Present in neurons within the hippocampus, frontal cortex and temporal cortex (at protein level). Expressed at low levels in most peripheral tissues and at higher levels in colon, kidney, pancreas, placenta, prostate, stomach and trachea. Expressed at low levels in the brain. Found in spinal cord, medulla oblongata, substantia nigra and locus coruleus. Expressed in the ductal epithelium of both normal and malignant prostate. {ECO:0000269|PubMed:10591213, ECO:0000269|PubMed:10677483, ECO:0000269|PubMed:10683441, ECO:0000269|PubMed:10749877, ECO:0000269|PubMed:10838186, ECO:0000269|PubMed:10965118, ECO:0000269|PubMed:11083922}.
Top Pathways	Alzheimer's disease

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human BACE2 ELISA Kit (Sandwich ELISA) - LS-F10912 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.312 Range 0.312-20 ng/ml

Human BACE2 ELISA Kit - abx054069 from Abbexa Category ELISA Kit Sensitivity 10 pg/ml Range 38 pg/ml - 2000 pg/ml

Beta-site APP Cleaving Enzyme 2, BACE2, Human, ELISA Kit - E-EL-H0575 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Beta-secretase 2 (BACE2), Human, ELISA Kit - E01B0734 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Beta-secretase 2, BACE2, Human, ELISA Kit - E1812h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.156-10 ng/mL

Beta-site APP-cleaving enzyme 2, BACE2, Human, ELISA Kit - CSB-E11867h from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Beta-site APP-cleaving enzyme 2, Human, ELISA Kit - E01B0635 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Beta-Site APP-Cleaving Enzyme 2, BACE2, Rat, ELISA Kit - E-EL-R0103 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Beta-site APP Cleaving Enzyme 2, BACE2, Rabbit, ELISA Kit - E-EL-RB0089 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Beta-site APP Cleaving Enzyme 2, BACE2, Chicken, ELISA Kit - E-EL-Ch0134 from ARP American Research Products Category ELISA Kit Prices $445.50 Sizes 96 t

Beta-site APP Cleaving Enzyme 2, BACE2, Porcine, ELISA Kit - E-EL-P1838 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Beta-site APP Cleaving Enzyme 2, BACE2, Sheep, ELISA Kit - E-EL-S0107 from ARP American Research Products Category ELISA Kit Prices $648.00 Sizes 96 t

Beta-site APP Cleaving Enzyme 2, BACE2, Guinea Pig, ELISA Kit - E-EL-GP0903 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Beta-site APP Cleaving Enzyme 2, BACE2, Monkey, ELISA Kit - E-EL-MK1563 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Human BACE 2 ELISA Kit - HB0642 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Anserine BACE 2 ELISA Kit - AB0642 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Human BACE2(Beta-Site APP Cleaving Enzyme 2) ELISA Kit - E-EL-H0575 from Elabscience Category ELISA Kit Sensitivity 0.10 ng/mL Range 0.16—10 ng/mL

BACE2, ELISA Kit - MBS2511909 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 3.75ng/mL Range 6.25-400ng/mL

BACE2, ELISA Kit - MBS2506028 from MyBioSource Category ELISA Kit Prices $490.00, $585.00, $2,475.00, $4,360.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

BACE2, ELISA Kit - MBS2507823 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156-10ng/mL

BACE2, ELISA Kit - MBS2500702 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156-10ng/mL

BACE2, ELISA Kit - MBS2511710 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 18.75ng/mL Range 31.25-2000ng/mL

BACE2, ELISA Kit - MBS2500708 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 18.75ng/mL Range 31.25-2000ng/mL

BACE2, ELISA Kit - MBS2501537 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156-10ng/mL

BACE2, ELISA Kit - MBS2510014 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.875ng/mL Range 3.125-200ng/mL

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