BACE2

Gene Symbol BACE2
Entrez Gene 25825
Alt Symbol AEPLC, ALP56, ASP1, ASP21, BAE2, CDA13, CEAP1, DRAP
Species Human
Gene Type protein-coding
Description beta-site APP-cleaving enzyme 2
Other Description 56 kDa aspartic-like protease|Down syndrome region aspartic protease|aspartyl protease 1|beta-secretase 2|beta-site amyloid beta A4 precursor protein-cleaving enzyme 2|memapsin-1|membrane-associated aspartic protease 1|theta-secretase|transmembrane aspartic proteinase Asp1
Swissprots Q8N2D4 A8K7P1 Q9NZL1 Q9Y5Z0 Q5DIH8 Q9H2V8 Q9NZL2 Q9UJT6
Accessions AAX14808 AAZ05450 CAB90458 CAB90554 EAX09611 EAX09612 EAX09613 Q9Y5Z0 AF050171 AAD45963 AF117892 AAD45240 AF178532 AAF29494 AF188276 AAF35835 AF188277 AAF35836 AF200192 AAF13714 AF200342 AAF17078 AF204944 AAF26368 AF212252 AAG41783 AK023647 AK075539 BAC11682 AK292056 BAF84745 AY358927 AAQ89286 AY429520 AY429521 BC014453 AAH14453 BC020582 BQ006998 DQ895416 ABM86342 EU176330 ABW03781 NM_012105 NP_036237 NM_138991 NP_620476 NM_138992 NP_620477
Function Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C- terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. {ECO:0000269|PubMed:10591213, ECO:0000269|PubMed:11083922, ECO:0000269|PubMed:11423558, ECO:0000269|PubMed:15857888, ECO:0000269|PubMed:16816112}.
Subcellular Location Membrane; Single-pass type I membrane protein. Golgi apparatus. Endoplasmic reticulum. Endosome. Cell surface.
Tissue Specificity Brain. Present in neurons within the hippocampus, frontal cortex and temporal cortex (at protein level). Expressed at low levels in most peripheral tissues and at higher levels in colon, kidney, pancreas, placenta, prostate, stomach and trachea. Expressed at low levels in the brain. Found in spinal cord, medulla oblongata, substantia nigra and locus coruleus. Expressed in the ductal epithelium of both normal and malignant prostate. {ECO:0000269|PubMed:10591213, ECO:0000269|PubMed:10677483, ECO:0000269|PubMed:10683441, ECO:0000269|PubMed:10749877, ECO:0000269|PubMed:10838186, ECO:0000269|PubMed:10965118, ECO:0000269|PubMed:11083922}.
Top Pathways Alzheimer's disease

BACE2 overexpression lysate - LY408426 from Acris Antibodies

Category Cell Lysate
Prices $480.00
Sizes 100 µg

BACE2 overexpression lysate - LY408427 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

BACE2 overexpression lysate - LY415975 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

BACE2 overexpression lysate - LY430078 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

BACE2 293 Cell Lysate - 407494 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

BACE-2 Overexpression Lysate (Native) - NBP2-07491 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: BACE2 Overexpression Lysate (Adult Normal) [NBP2-07491] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for BACE2.

BACE-2 Overexpression Lysate (Native) - NBP2-05612 from Novus Biologicals

Category Cell Lysate
Prices $529.00
Sizes 100 µg
Western Blot: BACE2 Overexpression Lysate (Adult Normal) [NBP2-05612] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for BACE2.

BACE2 (h2): 293 Lysate - sc-172845 from Santa Cruz Biotechnology

Category Cell Lysate
Prices $205.00
Sizes 100 µg/200 µl
Species Human

BACE2 Over-expression Lysate Product - GWB-9EDEDE from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

BACE-2 Overexpression Lysate (Native) - NBP2-09973 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: BACE2 Overexpression Lysate (Adult Normal) [NBP2-09973] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for BACE2.

Panoply™ Human BACE2 Knockdown Stable Cell Line - CSC-DC001292 from Creative biogene

Category Cell Line
Species Human
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