SETD7

Gene Symbol SETD7
Entrez Gene 80854
Alt Symbol KMT7, SET7, SET7/9, SET9
Species Human
Gene Type protein-coding
Description SET domain containing (lysine methyltransferase) 7
Other Description H3-K4-HMTase SETD7|SET domain-containing protein 7|histone H3-K4 methyltransferase SETD7|histone H3-lysine 4-specific methyltransferase|histone-lysine N-methyltransferase SETD7|lysine N-methyltransferase 7
Swissprots Q4W5A9 Q8WTS6 B5WWL3 Q9C0E6 Q0VAH3
Accessions AAY40937 EAX05114 Q8WTS6 AB051504 BAB21808 AF448510 AAL56579 AF462150 AAL69901 AI985614 AK024846 AK310856 BC012784 BC040990 BC066361 BC110904 BC121055 AAI21056 BC121056 AAI21057 BM922680 XM_011532288 XP_011530590 NM_001306199 NP_001293128 NM_001306200 NP_001293129 NM_030648 NP_085151 NR_131339
Function Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. {ECO:0000269|PubMed:12540855, ECO:0000269|PubMed:12588998, ECO:0000269|PubMed:15099517, ECO:0000269|PubMed:15525938, ECO:0000269|PubMed:16141209, ECO:0000269|PubMed:17108971}.
Subcellular Location Nucleus. Chromosome {ECO:0000305}.
Tissue Specificity Widely expressed. Expressed in pancreatic islets.
Top Pathways Lysine degradation

Human SETD7 / SET7 ELISA Kit (Sandwich ELISA) - LS-F8797 from LifeSpan Bioscience

Category ELISA Kit
Prices $790.00
Sizes 1 plate
Sensitivity 0.054 ng/ml
Range 0.156-10 ng/ml

SET domain containing (lysine methyltransferase) 7, ELISA Kit - MBS9320049 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ELISA Kit for SET Domain Containing Protein 7 (SETD7) - SEM701Hu from Uscn Life Science Inc.

Category ELISA Kit
Sensitivity The minimum detectable dose of this kit is typically less than 0.054ng/mL.
Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human SETD7 ELISA Kit - abx153068 from Abbexa

Category ELISA Kit
Sensitivity 0.054 ng/ml
Range 0.156 ng/ml - 10 ng/ml

SET Domain Containing Protein 7 (SETD7), Human, ELISA Kit - DL-SETD7-Hu from ARP American Research Products

Category ELISA Kit
Prices $655.00
Sizes 96 t
Range 0.156-10 ng/mL

Human SETD7 ELISA Kit - abx571534 from Abbexa

Category ELISA Kit
Sensitivity 0.054 ng/ml
Range 0.156 ng/ml - 10 ng/ml

Human SETD7 ELISA Kit - E035000 from Biobool

Category ELISA Kit
Sensitivity Typically less than 0.054ng/mL.

SETD7 ELISA Kit (Human) (OKDD00522) - OKDD00522 from Aviva Systems Biology

Category ELISA Kit
Prices $620.00
Sizes 96 wells
Sensitivity < 0.054 ng/mL
Range 0.156-10 ng/mL

Human Histone-lysine N-methyltransferase SETD7 (SETD7) ELISA Kit - AE19938HU from ARP American Research Products

Category ELISA Kit
Prices $549.00
Sizes 96 t
Sensitivity 0.054 ng/mL
Range 0.156-10 ng/mL

SET Domain Containing Protein 7 (SETD7), ELISA Kit - MBS455484 from MyBioSource

Category ELISA Kit
Prices $445.00, $590.00, $2,620.00, $5,095.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity <0.054ng/mL
Range 0.156-10ng/mL
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