SETD7

Gene Symbol	SETD7
Entrez Gene	80854
Alt Symbol	KMT7, SET7, SET7/9, SET9
Species	Human
Gene Type	protein-coding
Description	SET domain containing (lysine methyltransferase) 7
Other Description	H3-K4-HMTase SETD7|SET domain-containing protein 7|histone H3-K4 methyltransferase SETD7|histone H3-lysine 4-specific methyltransferase|histone-lysine N-methyltransferase SETD7|lysine N-methyltransferase 7
Swissprots	Q4W5A9 Q8WTS6 B5WWL3 Q9C0E6 Q0VAH3
Accessions	AAY40937 EAX05114 Q8WTS6 AB051504 BAB21808 AF448510 AAL56579 AF462150 AAL69901 AI985614 AK024846 AK310856 BC012784 BC040990 BC066361 BC110904 BC121055 AAI21056 BC121056 AAI21057 BM922680 XM_011532288 XP_011530590 NM_001306199 NP_001293128 NM_001306200 NP_001293129 NM_030648 NP_085151 NR_131339
Function	Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. {ECO:0000269|PubMed:12540855, ECO:0000269|PubMed:12588998, ECO:0000269|PubMed:15099517, ECO:0000269|PubMed:15525938, ECO:0000269|PubMed:16141209, ECO:0000269|PubMed:17108971}.
Subcellular Location	Nucleus. Chromosome {ECO:0000305}.
Tissue Specificity	Widely expressed. Expressed in pancreatic islets.
Top Pathways	Lysine degradation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human SETD7 full length protein - ab167960 from Abcam Category Protein Prices $239.00 Sizes 5 µg Source Baculovirus infected sf9 cells Species Human

Human SETD7 full length protein - ab51285 from Abcam Category Protein Source E. coli Species Human

SETD7 / SET7 Antibody Blocking Peptide - LS-E1320 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SETD7 / SET7 Antibody Blocking Peptide - LS-E1319 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SETD7 / SET7 Antibody Blocking Peptide - LS-E17701 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SETD7 Partial Recombinant Protein - H00080854-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human SETD7/9 Protein - NBC1-18444 from Novus Biologicals Category Protein Prices $249.00 Sizes 100 µg Source E.coli Species Human

SETD7 Peptide - P0259 from Novus Biologicals Category Peptide Species Human

SETD7 Peptide - P0258 from Novus Biologicals Category Peptide Species Human

Recombinant Human SETD7 Protein - P3518 from Novus Biologicals Category Protein Prices $449.00 Sizes 100 µg Source E. coli Species Human

SET7-Antibody-C-term-Blocking-Peptide - BP1194d from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SET7-SET9-Antibody-Center-Blocking-peptide - BP1194c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SETD7 Protein (OPPA00834) - OPPA00834 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 20 µg Source E. Coli

Human SETD7 His tag protein - orb83452 from Biorbyt Category Protein Prices $323.00, $646.00 Sizes 20 μg, 100 μg Source E. coli Species Human

Human SETD7 protein - orb90266 from Biorbyt Category Protein Prices $170.00, $289.00, $961.00 Sizes 20 μg, 100 μg, 1 mg Source E.coli Species Human

SETD7 Blocking Peptide - 33R-7322 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SETD7 / SET9 - SA6049 from Acris Antibodies Category Protein Prices $270.00 Sizes 100 µg Source E. coli Species Human

SETD7 / SET9 - SA6049X from Acris Antibodies Category Protein Prices $585.00 Sizes 500 µg Source E. coli Species Human

SETD7 / SET9 - H00080854-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

SETD7 / SET9 - H00080854-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

SETD7 / SET9 - P3518 from Acris Antibodies Category Protein Prices $430.00 Sizes 100 µg Species Human

Set7/9 Histone Methyltransferase, Human Recombinant - 228-11427-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Source Escherichia Coli. Species Human

Recombinant Human SETD7 - 228-11427-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source Escherichia Coli. Species Human

Recombinant Human SETD7 - 228-11427-3 from RayBiotech Category Protein Prices $1,190.00 Sizes 3 µg Source Escherichia Coli. Species Human

SET7/9 Histone methyltransferase Human, Recombinant, E.coli - 01-2217 from ARP American Research Products Category Protein Prices $139.00, $299.00, $639.00 Sizes 20 µg, 100 µg, 500 µg Source E.coli Species Human

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