SETD7

Gene Symbol SETD7
Entrez Gene 80854
Alt Symbol KMT7, SET7, SET7/9, SET9
Species Human
Gene Type protein-coding
Description SET domain containing (lysine methyltransferase) 7
Other Description H3-K4-HMTase SETD7|SET domain-containing protein 7|histone H3-K4 methyltransferase SETD7|histone H3-lysine 4-specific methyltransferase|histone-lysine N-methyltransferase SETD7|lysine N-methyltransferase 7
Swissprots Q4W5A9 Q8WTS6 B5WWL3 Q9C0E6 Q0VAH3
Accessions AAY40937 EAX05114 Q8WTS6 AB051504 BAB21808 AF448510 AAL56579 AF462150 AAL69901 AI985614 AK024846 AK310856 BC012784 BC040990 BC066361 BC110904 BC121055 AAI21056 BC121056 AAI21057 BM922680 XM_011532288 XP_011530590 NM_001306199 NP_001293128 NM_001306200 NP_001293129 NM_030648 NP_085151 NR_131339
Function Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. {ECO:0000269|PubMed:12540855, ECO:0000269|PubMed:12588998, ECO:0000269|PubMed:15099517, ECO:0000269|PubMed:15525938, ECO:0000269|PubMed:16141209, ECO:0000269|PubMed:17108971}.
Subcellular Location Nucleus. Chromosome {ECO:0000305}.
Tissue Specificity Widely expressed. Expressed in pancreatic islets.
Top Pathways Lysine degradation

SET7/SET9 (C24B1) Rabbit mAb - 2825 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone C24B1
Western blot analysis of extracts from various cell lines using SET7/SET9 (C24B1) Rabbit mAb.

SET7/SET9 Antibody - 2813 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of cell lysates from HeLa, NIH/3T3, C6 and COS cells using SET7/SET9 Antibody.

SET7/9 (C-11) - sc-390823 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SET7/9 (C-11): sc-390823. Western blot analysis of SET7/9 expression in HeLa nuclear extract (A) and NIH/3T3 whole cell lysate (B).

SET7/9 (V-20) - sc-28114 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SET7/9 (V-20): sc-28114. Western blot analysis of SET7/9 expression in HeLa nuclear extract.

SET7/9 (N-20) - sc-28113 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

SET7/9 (H-300) - sc-366944 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

SET7/9 (s4E5) - sc-56774 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
SET7/9 (s4E5): sc-56774. Western blot analysis of recombinant human SET7/9.

Anti-SETD7 antibody - ab135494 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-SETD7 antibody (ab135494) at 1/100 dilution + Mouse brain tissue lysate at 12.5 µg

Anti-SETD7 antibody (Biotin) - ab79655 from Abcam

Prices $370.00
Sizes 150 µg
Host Rabbit
Clonality Polyclonal

Anti-SETD7 antibody [EPR5574] - ab124708 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5574
All lanes : Anti-SETD7 antibody [EPR5574] (ab124708) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : BxPC-3 cell lysateLane 3 : Jurkat cell lysateLane 4 : MCF-7 cell lysateLane 5 : C6 cell lysateLane 6 : RAW264.7 cell lysateLane 7 : PC-12 cell lysateLane 8 : NIH/3T3 cell lysateLysates/proteins at 10 µg per lane.

Anti-SETD7 antibody [s4E5] - ChIP Grade - ab14820 from Abcam

Prices $387.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone s4E5

Anti-SETD7 antibody - C-terminal - ab71214 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-SETD7 antibody - C-terminal (ab71214) at 1/70 dilution + Mouse brain tissue lysate at 35 µg

Anti-SETD7 antibody - ChIP Grade - ab13731 from Abcam

Prices $378.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis fof Set7 using ab13731 at 1:500 on 20 ugs of HeLa whole cell lysate.

Anti-SETD7 / SET7 Antibody (aa316-366) - LS-C286826 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human SET7 by Immunohistochemistry. Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-SET7 used at a dilution of 1:250.

Anti-SETD7 / SET7 Antibody (clone 5B11) - LS-C173211 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 5B11
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SETD7 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-SETD7.

Anti-SETD7 / SET7 Antibody (clone 5B4) IHC-plus™ - LS-B8443 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 5B4
Anti-SETD7 / SET7 antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B8443 dilution 5 ug/ml.

Anti-SETD7 / SET7 Antibody (aa316-366) - LS-C288532 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human SET7 by Immunohistochemistry. Sample: FFPE section of human prostate carcinoma. Antibody: Affinity purified rabbit anti-SET7 used at a dilution of 1:1000 (0.2 ug/ml). Detection: DAB.

Anti-SETD7 / SET7 Antibody (aa131-145) IHC-plus™ - LS-B6487 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-SETD7 / SET7 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6487 dilution 1:100.

Anti-SETD7 / SET7 Antibody (aa159-189) - LS-C98686 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.

Anti-SETD7 / SET7 Antibody (clone 2E3) - LS-C173221 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2E3
Western blot of extracts (35 ug) from 9 different cell lines by using anti-SETD7 monoclonal antibody (HepG2: human; HeLa: human; SVT2: mouse; A549: human; COS7: monkey; Jurkat: human; MDCK: canine; PC12: rat; MCF7: human).

Anti-SETD7 / SET7 Antibody (clone S4E5) IHC-plus™ - LS-B2921 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone S4E5
Anti-SETD7 / SET7 antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2921 concentration 5 ug/ml.

Anti-SETD7 / SET7 Antibody (clone 2D10) - LS-C337450 from LifeSpan Bioscience

Prices $350.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2D10
IHC of paraffin-embedded Carcinoma of Human bladder tissue using anti-SETD7 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min).

Anti-SETD7 / SET7 Antibody (aa316-366) - LS-C91359 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SETD7 / SET7 Antibody (C-Terminus) - LS-C81327 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Fetal pancreas cell lysate. Antibody concentration: 5.0 ug/ml. Gel concentration: 12%.

Anti-SETD7 / SET7 Antibody (clone 2967C2a) - LS-C184784 from LifeSpan Bioscience

Prices $335.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 2967C2a
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