SETD7
| Gene Symbol | SETD7 |
|---|---|
| Entrez Gene | 80854 |
| Alt Symbol | KMT7, SET7, SET7/9, SET9 |
| Species | Human |
| Gene Type | protein-coding |
| Description | SET domain containing (lysine methyltransferase) 7 |
| Other Description | H3-K4-HMTase SETD7|SET domain-containing protein 7|histone H3-K4 methyltransferase SETD7|histone H3-lysine 4-specific methyltransferase|histone-lysine N-methyltransferase SETD7|lysine N-methyltransferase 7 |
| Swissprots | Q4W5A9 Q8WTS6 B5WWL3 Q9C0E6 Q0VAH3 |
| Accessions | AAY40937 EAX05114 Q8WTS6 AB051504 BAB21808 AF448510 AAL56579 AF462150 AAL69901 AI985614 AK024846 AK310856 BC012784 BC040990 BC066361 BC110904 BC121055 AAI21056 BC121056 AAI21057 BM922680 XM_011532288 XP_011530590 NM_001306199 NP_001293128 NM_001306200 NP_001293129 NM_030648 NP_085151 NR_131339 |
| Function | Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. {ECO:0000269|PubMed:12540855, ECO:0000269|PubMed:12588998, ECO:0000269|PubMed:15099517, ECO:0000269|PubMed:15525938, ECO:0000269|PubMed:16141209, ECO:0000269|PubMed:17108971}. |
| Subcellular Location | Nucleus. Chromosome {ECO:0000305}. |
| Tissue Specificity | Widely expressed. Expressed in pancreatic islets. |
| Top Pathways | Lysine degradation |
SET7/9 CRISPR/Cas9 KO Plasmid (h) - sc-405251 from Santa Cruz Biotechnology
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SET7/9 HDR Plasmid (h) - sc-405251-HDR from Santa Cruz Biotechnology
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SET7/9 Double Nickase Plasmid (h) - sc-405251-NIC from Santa Cruz Biotechnology
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SET7/9 Double Nickase Plasmid (h2) - sc-405251-NIC-2 from Santa Cruz Biotechnology
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SET7/9 CRISPR Activation Plasmid (h) - sc-405251-ACT from Santa Cruz Biotechnology
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SET7/9 CRISPR Activation Plasmid (h2) - sc-405251-ACT-2 from Santa Cruz Biotechnology
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SET7/9 Lentiviral Activation Particles (h) - sc-405251-LAC from Santa Cruz Biotechnology
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SET7/9 Lentiviral Activation Particles (h2) - sc-405251-LAC-2 from Santa Cruz Biotechnology
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SET7/9 siRNA (h) - sc-44094 from Santa Cruz Biotechnology
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SET7/9 shRNA Plasmid (h) - sc-44094-SH from Santa Cruz Biotechnology
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SET7/9 shRNA (h) Lentiviral Particles - sc-44094-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU001041 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19172 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19172 from Sigma-Aldrich
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SETD7 siRNA (Human) - CRJ2935 from Cohesion Biosciences
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SETD7 RNAi - H00080854-R01 from Novus Biologicals
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SETD7 - MBS8226124 from MyBioSource
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shRNA set against Human SETD7 (NM_030648.2) - SHH405644 from Creative biogene
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shRNA set against Human SETD7(NM_030648.2) - SHR218848 from Creative biogene
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SETD7 shRNA Plasmid (Human) - CHJ2935 from Cohesion Biosciences
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SETD7 miRNA 3'UTR clone - MiUTR1H-09315 from Creative biogene
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