SETD7

Gene Symbol	SETD7
Entrez Gene	80854
Alt Symbol	KMT7, SET7, SET7/9, SET9
Species	Human
Gene Type	protein-coding
Description	SET domain containing (lysine methyltransferase) 7
Other Description	H3-K4-HMTase SETD7|SET domain-containing protein 7|histone H3-K4 methyltransferase SETD7|histone H3-lysine 4-specific methyltransferase|histone-lysine N-methyltransferase SETD7|lysine N-methyltransferase 7
Swissprots	Q4W5A9 Q8WTS6 B5WWL3 Q9C0E6 Q0VAH3
Accessions	AAY40937 EAX05114 Q8WTS6 AB051504 BAB21808 AF448510 AAL56579 AF462150 AAL69901 AI985614 AK024846 AK310856 BC012784 BC040990 BC066361 BC110904 BC121055 AAI21056 BC121056 AAI21057 BM922680 XM_011532288 XP_011530590 NM_001306199 NP_001293128 NM_001306200 NP_001293129 NM_030648 NP_085151 NR_131339
Function	Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. {ECO:0000269|PubMed:12540855, ECO:0000269|PubMed:12588998, ECO:0000269|PubMed:15099517, ECO:0000269|PubMed:15525938, ECO:0000269|PubMed:16141209, ECO:0000269|PubMed:17108971}.
Subcellular Location	Nucleus. Chromosome {ECO:0000305}.
Tissue Specificity	Widely expressed. Expressed in pancreatic islets.
Top Pathways	Lysine degradation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human-SETD7-cDNA-Clone - DC14205 from Abgent, a WuXi AppTec company Prices $494.10 Sizes 10 µg Species Human Accession BC121055

SETD7 - MBS1265703 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC121055

Human SETD7 cDNA clone(NM_030648.2) - CDFG005093 from Creative Biomart Species Human Accession NM_030648.2

Human SETD7 ORF clone(NM_030648.2) - CDCL186153 from Creative Biomart Species Human Accession NM_030648.2

Human SETD7 ORF Clone(NM_030648.2) - CDCL175173 from Creative Biomart Species Human Accession NM_030648.2

Human SETD7 ORF Clone(NM_030648.2) - CDCR310509 from Creative Biomart Species Human Accession NM_030648.2

Human SETD7 ORF Clone(NM_030648.2) - CDCR310510 from Creative Biomart Species Human Accession NM_030648.2

Human SETD7 ORF Clone(NM_030648.2) - CDCR310511 from Creative Biomart Species Human Accession NM_030648.2

human SETD7 ORF clone - CDCH079046 from Creative Biomart Species Human Accession NM_030648

human SETD7 ORF clone - CDCH079047 from Creative Biomart Species Human Accession NM_030648

Human SETD7/SET7/9 Gene ORF cDNA clone in cloning vector - HG11209-M from Sino Biological Species Human

Human SETD7/SET7/9 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG11209-ANG from Sino Biological Species Human

Human SETD7/SET7/9 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG11209-ACG from Sino Biological Species Human

Human SETD7/SET7/9 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG11209-NF from Sino Biological Species Human

Human SETD7/SET7/9 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG11209-NM from Sino Biological Species Human

Human SETD7/SET7/9 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG11209-CF from Sino Biological Species Human

Human SETD7/SET7/9 Gene ORF cDNA clone expression plasmid, N-HA tag - HG11209-NY from Sino Biological Species Human

Human SETD7/SET7/9 Gene ORF cDNA clone expression plasmid, N-His tag - HG11209-NH from Sino Biological Species Human

Human SETD7/SET7/9 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG11209-CM from Sino Biological Species Human

Human SETD7/SET7/9 Gene ORF cDNA clone expression plasmid, C-His tag - HG11209-CH from Sino Biological Species Human

Human SETD7/SET7/9 Gene ORF cDNA clone expression plasmid, C-HA tag - HG11209-CY from Sino Biological Species Human

Human SETD7 / SET7 / 9 Gene cDNA Clone (full-length ORF Clone), expression ready, FLAG-tagged - HG11209-M-F from Sino Biological Species Human Accession NM_030648.2

Human SETD7/SET7/9 Gene ORF cDNA clone expression plasmid - HG11209-M-N from Sino Biological Species Human

Human SETD7/SET7/9 Gene ORF cDNA clone expression plasmid, C-HA tag - HG11209-M-Y from Sino Biological Species Human

Human SETD7/SET7/9 Gene ORF cDNA clone expression plasmid - HG11209-UT from Sino Biological Species Human

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