| Gene Symbol |
SETD7
|
| Entrez Gene |
80854
|
| Alt Symbol |
KMT7, SET7, SET7/9, SET9
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SET domain containing (lysine methyltransferase) 7
|
| Other Description |
H3-K4-HMTase SETD7|SET domain-containing protein 7|histone H3-K4 methyltransferase SETD7|histone H3-lysine 4-specific methyltransferase|histone-lysine N-methyltransferase SETD7|lysine N-methyltransferase 7
|
| Swissprots |
Q4W5A9 Q8WTS6 B5WWL3 Q9C0E6 Q0VAH3
|
| Accessions |
AAY40937 EAX05114 Q8WTS6 AB051504 BAB21808 AF448510 AAL56579 AF462150 AAL69901 AI985614 AK024846 AK310856 BC012784 BC040990 BC066361 BC110904 BC121055 AAI21056 BC121056 AAI21057 BM922680 XM_011532288 XP_011530590 NM_001306199 NP_001293128 NM_001306200 NP_001293129 NM_030648 NP_085151 NR_131339
|
| Function |
Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. {ECO:0000269|PubMed:12540855, ECO:0000269|PubMed:12588998, ECO:0000269|PubMed:15099517, ECO:0000269|PubMed:15525938, ECO:0000269|PubMed:16141209, ECO:0000269|PubMed:17108971}.
|
| Subcellular Location |
Nucleus. Chromosome {ECO:0000305}.
|
| Tissue Specificity |
Widely expressed. Expressed in pancreatic islets.
|
| Top Pathways |
Lysine degradation
|
![Western Blot: SETD7 Overexpression Lysate (Adult Normal) [NBL1-15869] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SETD7.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7026_SETD7%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-15869-img0002.jpg)