| Gene Symbol |
Gckr
|
| Entrez Gene |
231103
|
| Alt Symbol |
GKRP
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
glucokinase regulatory protein
|
| Other Description |
glucokinase regulator
|
| Swissprots |
Q91X44
|
| Accessions |
EDL37365 EDL37366 Q91X44 AK149377 BC012412 AAH12412 XM_006503881 XP_006503944 XM_006503882 XP_006503945 XM_006503883 XP_006503946 NM_144909 NP_659158
|
| Function |
Inhibits glucokinase (GCK) by forming an inactive complex with this enzyme. The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6- phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Under low glucose concentrations, GCK associates with GKRP and the inactive complex is recruited to the hepatocyte nucleus. {ECO:0000250}.
|