Gene Symbol | Gckr |
---|---|
Entrez Gene | 231103 |
Alt Symbol | GKRP |
Species | Mouse |
Gene Type | protein-coding |
Description | glucokinase regulatory protein |
Other Description | glucokinase regulator |
Swissprots | Q91X44 |
Accessions | EDL37365 EDL37366 Q91X44 AK149377 BC012412 AAH12412 XM_006503881 XP_006503944 XM_006503882 XP_006503945 XM_006503883 XP_006503946 NM_144909 NP_659158 |
Function | Inhibits glucokinase (GCK) by forming an inactive complex with this enzyme. The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6- phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Under low glucose concentrations, GCK associates with GKRP and the inactive complex is recruited to the hepatocyte nucleus. {ECO:0000250}. |
Recombinant Mouse Glucokinase regulatory protein(Gckr) - CSB-YP852791MO CSB-EP852791MO CSB-BP852791MO CSB-MP852791MO from Cusabio
|
||||||||||
GCKR Recombinant Protein (OPCD03560) - OPCD03560 from Aviva Systems Biology
|
||||||||||
Glucokinase regulatory protein (Gckr), Recombinant Protein - MBS1488042 from MyBioSource
|
||||||||||