Gene Symbol | Gckr |
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Entrez Gene | 231103 |
Alt Symbol | GKRP |
Species | Mouse |
Gene Type | protein-coding |
Description | glucokinase regulatory protein |
Other Description | glucokinase regulator |
Swissprots | Q91X44 |
Accessions | EDL37365 EDL37366 Q91X44 AK149377 BC012412 AAH12412 XM_006503881 XP_006503944 XM_006503882 XP_006503945 XM_006503883 XP_006503946 NM_144909 NP_659158 |
Function | Inhibits glucokinase (GCK) by forming an inactive complex with this enzyme. The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6- phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Under low glucose concentrations, GCK associates with GKRP and the inactive complex is recruited to the hepatocyte nucleus. {ECO:0000250}. |
GCKR CRISPR/Cas9 KO Plasmid (m) - sc-433037 from Santa Cruz Biotechnology
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GCKR HDR Plasmid (m) - sc-433037-HDR from Santa Cruz Biotechnology
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GCKR Double Nickase Plasmid (m) - sc-433037-NIC from Santa Cruz Biotechnology
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GCKR Double Nickase Plasmid (m2) - sc-433037-NIC-2 from Santa Cruz Biotechnology
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GCKR CRISPR Activation Plasmid (m) - sc-433037-ACT from Santa Cruz Biotechnology
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GCKR CRISPR Activation Plasmid (m2) - sc-433037-ACT-2 from Santa Cruz Biotechnology
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GCKR Lentiviral Activation Particles (m) - sc-433037-LAC from Santa Cruz Biotechnology
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GCKR Lentiviral Activation Particles (m2) - sc-433037-LAC-2 from Santa Cruz Biotechnology
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GCKR siRNA (m) - sc-35461 from Santa Cruz Biotechnology
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GCKR shRNA Plasmid (m) - sc-35461-SH from Santa Cruz Biotechnology
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GCKR shRNA (m) Lentiviral Particles - sc-35461-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN31790 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND31790 from Sigma-Aldrich
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GCKR siRNA (Mouse) - CRN2882 from Cohesion Biosciences
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GCKR - MBS8205231 from MyBioSource
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shRNA set against Mouse GCKR (NM_144909.1) - SHH300038 from Creative biogene
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shRNA set against Mouse Gckr(NM_144909.1) - SHH079949 from Creative biogene
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GCKR shRNA Plasmid (Mouse) - CHN2882 from Cohesion Biosciences
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GCKR miRNA 3'UTR clone - MiUTR1M-04978 from Creative biogene
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