Gene Symbol | IL12RB2 |
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Entrez Gene | 3595 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | interleukin 12 receptor, beta 2 |
Other Description | IL-12 receptor subunit beta-2|IL-12R subunit beta-2|interleukin-12 receptor beta-2 chain|interleukin-12 receptor subunit beta-2 |
Swissprots | Q2M3V3 Q99665 B7ZKL9 B1AN98 F5H7L6 |
Accessions | AAT45456 EAX06499 EAX06500 Q99665 AK294494 BAG57715 AK300020 BAG61833 AK310837 AK316525 BAH14896 BC104772 AAI04773 BC104774 AAI04775 BC143248 BC143249 AAI43250 BC143250 BC143252 DA223630 DB126833 U64198 AAB36675 XM_005270825 XP_005270882 XM_005270827 XP_005270884 XM_005270828 XP_005270885 XM_006710617 XP_006710680 XM_011541383 XP_011539685 XM_011541384 XP_011539686 XM_011541385 XP_011539687 NM_001258214 NP_001245143 NM_001258215 NP_001245144 NM_001258216 NP_001245145 NM_001559 NP_001550 NR_047583 NR_047584 |
Function | Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production. |
Subcellular Location | Membrane; Single-pass type I membrane protein. |
Tissue Specificity | Isoform 2 is expressed at similar levels in both naive and activated T-cells. {ECO:0000269|PubMed:9120388}. |
Top Pathways | Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Inflammatory bowel disease (IBD) |
IL-12Rβ2 (E-20) - sc-18648 from Santa Cruz Biotechnology
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Anti-IL12RB2 antibody - ab198833 from Abcam
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Anti-IL12RB2 antibody - ab96097 from Abcam
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Anti-IL12RB2 antibody - ab107204 from Abcam
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Anti-IL12RB2 antibody - ab67365 from Abcam
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Anti-IL12RB2 Antibody - LS-C143930 from LifeSpan Bioscience
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Anti-IL12RB2 Antibody (aa24-622, PE) - LS-C125812 from LifeSpan Bioscience
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Anti-IL12RB2 Antibody (aa759-788, AP) - LS-C215239 from LifeSpan Bioscience
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Anti-IL12RB2 Antibody (aa759-788, APC) - LS-C215240 from LifeSpan Bioscience
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Anti-IL12RB2 Antibody (aa759-788, Azide-free, HRP) - LS-C215244 from LifeSpan Bioscience
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Anti-IL12RB2 Antibody (aa24-622, clone 305719, APC) - LS-C125813 from LifeSpan Bioscience
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Anti-IL12RB2 Antibody (aa759-788, Biotin) - LS-C215241 from LifeSpan Bioscience
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Anti-IL12RB2 Antibody (aa759-788, FITC) - LS-C215242 from LifeSpan Bioscience
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Anti-IL12RB2 Antibody (aa759-788, PE) - LS-C215245 from LifeSpan Bioscience
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Anti-IL12RB2 Antibody (aa323-695) - LS-C185526 from LifeSpan Bioscience
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Anti-IL12RB2 Antibody (aa559-647, FITC) - LS-C302759 from LifeSpan Bioscience
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Anti-IL12RB2 Antibody (aa559-647, Biotin) - LS-C298983 from LifeSpan Bioscience
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Anti-IL12RB2 Antibody (aa285-441, Biotin) - LS-C297166 from LifeSpan Bioscience
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Anti-IL12RB2 Antibody (aa455-606, Biotin) - LS-C299860 from LifeSpan Bioscience
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Anti-IL12RB2 Antibody (aa285-441, FITC) - LS-C303962 from LifeSpan Bioscience
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Anti-IL12RB2 Antibody - LS-C308441 from LifeSpan Bioscience
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Anti-IL12RB2 Antibody (aa455-606, FITC) - LS-C304743 from LifeSpan Bioscience
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Anti-IL12RB2 Antibody (clone 2H6) - LS-C197525 from LifeSpan Bioscience
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Anti-IL12RB2 Antibody - LS-C310736 from LifeSpan Bioscience
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Anti-IL12RB2 Antibody (aa326-375) - LS-C205749 from LifeSpan Bioscience
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