| Gene Symbol |
IL12RB2
|
| Entrez Gene |
3595
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
interleukin 12 receptor, beta 2
|
| Other Description |
IL-12 receptor subunit beta-2|IL-12R subunit beta-2|interleukin-12 receptor beta-2 chain|interleukin-12 receptor subunit beta-2
|
| Swissprots |
Q2M3V3 Q99665 B7ZKL9 B1AN98 F5H7L6
|
| Accessions |
AAT45456 EAX06499 EAX06500 Q99665 AK294494 BAG57715 AK300020 BAG61833 AK310837 AK316525 BAH14896 BC104772 AAI04773 BC104774 AAI04775 BC143248 BC143249 AAI43250 BC143250 BC143252 DA223630 DB126833 U64198 AAB36675 XM_005270825 XP_005270882 XM_005270827 XP_005270884 XM_005270828 XP_005270885 XM_006710617 XP_006710680 XM_011541383 XP_011539685 XM_011541384 XP_011539686 XM_011541385 XP_011539687 NM_001258214 NP_001245143 NM_001258215 NP_001245144 NM_001258216 NP_001245145 NM_001559 NP_001550 NR_047583 NR_047584
|
| Function |
Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production.
|
| Subcellular Location |
Membrane; Single-pass type I membrane protein.
|
| Tissue Specificity |
Isoform 2 is expressed at similar levels in both naive and activated T-cells. {ECO:0000269|PubMed:9120388}.
|
| Top Pathways |
Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Inflammatory bowel disease (IBD)
|
![Western Blot: IL12RB2 Overexpression Lysate (Adult Normal) [NBL1-11903] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for IL12RB2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8011_IL12RB2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-11903-img0002.jpg)