IL12RB2

Gene Symbol	IL12RB2
Entrez Gene	3595
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	interleukin 12 receptor, beta 2
Other Description	IL-12 receptor subunit beta-2|IL-12R subunit beta-2|interleukin-12 receptor beta-2 chain|interleukin-12 receptor subunit beta-2
Swissprots	Q2M3V3 Q99665 B7ZKL9 B1AN98 F5H7L6
Accessions	AAT45456 EAX06499 EAX06500 Q99665 AK294494 BAG57715 AK300020 BAG61833 AK310837 AK316525 BAH14896 BC104772 AAI04773 BC104774 AAI04775 BC143248 BC143249 AAI43250 BC143250 BC143252 DA223630 DB126833 U64198 AAB36675 XM_005270825 XP_005270882 XM_005270827 XP_005270884 XM_005270828 XP_005270885 XM_006710617 XP_006710680 XM_011541383 XP_011539685 XM_011541384 XP_011539686 XM_011541385 XP_011539687 NM_001258214 NP_001245143 NM_001258215 NP_001245144 NM_001258216 NP_001245145 NM_001559 NP_001550 NR_047583 NR_047584
Function	Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production.
Subcellular Location	Membrane; Single-pass type I membrane protein.
Tissue Specificity	Isoform 2 is expressed at similar levels in both naive and activated T-cells. {ECO:0000269|PubMed:9120388}.
Top Pathways	Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Inflammatory bowel disease (IBD)

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human IL12RB2 full length protein - ab158762 from Abcam Category Protein Source Wheat germ Species Human

Human IL12RB2 protein fragment - ab116889 from Abcam Category Protein Source Wheat germ Species Human

IL12RB2 Antibody Blocking Peptide - LS-E408 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human IL-12 R beta 2 Protein - H00003595-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

IL12_2-Antibody-C-term-Blocking-peptide - BP10687b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human IL-12 R beta 2 Fc Chimera, CF - 1959-B2-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

Human IL12RB2 protein - orb246185 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human IL12Rb2 Protein - abx067436 from Abbexa Category Protein Source E.coli Species Human

Human IL12Rb2 Protein - abx067439 from Abbexa Category Protein Source E.coli Species Human

IL12RB2 - H00003595-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

IL12RB2 - H00003595-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

IL12RB2 - H00003595-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Interleukin 12 Receptor Beta 2 (IL12Rb2), Human - 20-7447 from ARP American Research Products Category Protein Prices $511.00 Sizes 50 µg Source E.coli Species Human

IL12RB2 fusion protein - ag13619 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

IL12RB2 fusion protein - ag13652 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human IL12RB2 - IL12RB2-29640TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Interleukin 12 Receptor Beta 2 (IL12Rb2) - RPB073Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Interleukin 12 Receptor Beta 2 (IL12Rb2) - RPB073Hu02 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Interleukin 12 Receptor Beta 2 (IL12Rb2) - RPB073Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Interleukin 12 Receptor Beta 2 (IL12Rb2) - RPB073Mu02 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Human Interleukin-12 receptor subunit beta-2(IL12RB2) - CSB-EP859518HU CSB-BP859518HU CSB-MP859518HU from Cusabio Category Protein Source E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human Interleukin-12 receptor subunit beta-2(IL12RB2) - CSB-YP859518HU from Cusabio Category Protein Source Yeast Species Human

Recombinant Human IL-12 R beta 2 Fc Chimera Protein, CF - 1959-B2 from R&D Systems Category Protein Prices $329.00 Sizes 50 µg Source Mouse myeloma cell line, NS0-derived Human IL-12 R beta 2 (Cys28-Asn622) Accession # Q99665 IEGRMD Human IgG 1 (Pro100-Lys330) 6-His tag N-terminus C-terminus Species Human

IL-12 R beta 2 Recombinant Protein Antigen - NBP1-85983PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

IL12RB2 Peptide, Human - M34GP07536H from Creative Peptides Category Peptide Source Synthetic. Species Human

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