IL12RB2

Gene Symbol IL12RB2
Entrez Gene 3595
Alt Symbol -
Species Human
Gene Type protein-coding
Description interleukin 12 receptor, beta 2
Other Description IL-12 receptor subunit beta-2|IL-12R subunit beta-2|interleukin-12 receptor beta-2 chain|interleukin-12 receptor subunit beta-2
Swissprots Q2M3V3 Q99665 B7ZKL9 B1AN98 F5H7L6
Accessions AAT45456 EAX06499 EAX06500 Q99665 AK294494 BAG57715 AK300020 BAG61833 AK310837 AK316525 BAH14896 BC104772 AAI04773 BC104774 AAI04775 BC143248 BC143249 AAI43250 BC143250 BC143252 DA223630 DB126833 U64198 AAB36675 XM_005270825 XP_005270882 XM_005270827 XP_005270884 XM_005270828 XP_005270885 XM_006710617 XP_006710680 XM_011541383 XP_011539685 XM_011541384 XP_011539686 XM_011541385 XP_011539687 NM_001258214 NP_001245143 NM_001258215 NP_001245144 NM_001258216 NP_001245145 NM_001559 NP_001550 NR_047583 NR_047584
Function Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production.
Subcellular Location Membrane; Single-pass type I membrane protein.
Tissue Specificity Isoform 2 is expressed at similar levels in both naive and activated T-cells. {ECO:0000269|PubMed:9120388}.
Top Pathways Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Inflammatory bowel disease (IBD)

IL-12Rβ2 siRNA (h) - sc-40033 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

IL-12Rβ2 shRNA Plasmid (h) - sc-40033-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

IL-12Rβ2 shRNA (h) Lentiviral Particles - sc-40033-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

IL-12 R beta 2 RNAi - H00003595-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU160761 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN10568 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10568 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR06849 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr06849

IL12RB2 siRNA (Human) - CRH2404 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

IL12RB2 - MBS8238036 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human IL12 (NM_001559.2) - SHH318165 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human IL12RB2(NM_001559.2) - SHL171318 from Creative biogene

Category siRNA
Species Reactivities Human

Human IL12RB2 siRNA - orb262906 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

IL12RB2 shRNA Plasmid (Human) - CHH2404 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

IL12RB2 miRNA 3'UTR clone - MiUTR1H-04873 from Creative biogene

Species Reactivities Human
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