| Gene Symbol | SELP |
|---|---|
| Entrez Gene | 6403 |
| Alt Symbol | CD62, CD62P, GMP140, GRMP, LECAM3, PADGEM, PSEL |
| Species | Human |
| Gene Type | protein-coding |
| Description | selectin P (granule membrane protein 140kDa, antigen CD62) |
| Other Description | CD62 antigen-like family member P|GMP-140|P-selectin|granule membrane protein 140|granulocyte membrane protein|leukocyte-endothelial cell adhesion molecule 3|platelet activation dependent granule-external membrane protein|platelet alpha-granule membrane protein |
| Swissprots | P16109 Q8IVD1 Q5R344 |
| Accessions | AAA35910 AAC31762 AAN06828 EAW90850 EAW90851 EAW90852 EAW90853 EAW90854 P16109 AK312884 BAG35732 AY367063 AAQ67703 BC028067 AAH28067 BC068533 AAH68533 DA926598 DA994564 M25322 AAA35911 XM_005245435 XP_005245492 XM_005245436 XP_005245493 XM_005245438 XP_005245495 XM_005245439 XP_005245496 XM_005245440 XP_005245497 NM_003005 NP_002996 |
| Function | Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1. {ECO:0000269|PubMed:7585950}. |
| Subcellular Location | Membrane; Single-pass type I membrane protein. |
| Tissue Specificity | Stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Upon cell activation by agonists, P-selectin is transported rapidly to the cell surface. |
| Top Pathways | Cell adhesion molecules (CAMs), Staphylococcus aureus infection, Malaria |