TFRC

Gene Symbol TFRC
Entrez Gene 7037
Alt Symbol CD71, T9, TFR, TFR1, TR, TRFR, p90
Species Human
Gene Type protein-coding
Description transferrin receptor
Other Description transferrin receptor (p90, CD71)|transferrin receptor protein 1
Swissprots Q9UDF9 Q1HE24 Q9UCN0 Q59G55 Q9UCU5 D3DXB0 P02786 Q9UK21
Accessions AAF04564 ABF47088 EAW53670 EAW53671 EAW53672 EAW53673 P02786 AB209254 BAD92491 AK291723 BAF84412 AK294758 BAH11872 AK309923 BC001188 AAH01188 BX537966 CAD97930 CK724857 DA460386 DQ892859 ABM83785 DQ896108 ABM87107 DT219054 M11507 AAA61153 X01060 CAA25527 XM_011513112 XP_011511414 NM_001128148 NP_001121620 NM_003234 NP_003225
Function Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. {ECO:0000250, ECO:0000269|PubMed:3568132}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:17081065}; Single-pass type II membrane protein {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Top Pathways Hematopoietic cell lineage, Endocytosis, Phagosome

TFRC overexpression lysate - LY426898 from Acris Antibodies

Category Cell Lysate
Prices $480.00
Sizes 100 µg

TfR (Transferrin R) Overexpression Lysate (Native) - NBP2-08027 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: Transferrin Receptor Overexpression Lysate (Native) [NBP2-08027] - Transferrin Receptor Overexpression Lysate (Native) Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for TFRC.

CD71 (h): 293T Lysate - sc-175273 from Santa Cruz Biotechnology

Category Cell Lysate
Prices $205.00
Sizes 100 µg/200 µl
Species Human

Cynomolgus Transferrin Receptor / TFRC / CD71 HEK293 Cell Lysate (WB positive control) - 90253-C07HL-300 from Sino Biological

Category Cell Lysate
Prices $195.00
Sizes 300 µg
Species Cynomolgus

Human Transferrin Receptor / TFRC / CD71 HEK293 Cell Lysate (WB positive control) - 11020-H07HL-300 from Sino Biological

Category Cell Lysate
Prices $195.00
Sizes 300 µg
Species Human

Human TFRC Human Cells Transfected Lysate (positive control) (denatured) - orb173691 from Biorbyt

Category Cell Lysate
Prices $425.00
Sizes 300 μg
Species Human

TfR (Transferrin R) Overexpression Lysate (Native) - NBP2-09467 from Novus Biologicals

Category Cell Lysate
Prices $529.00
Sizes 100 µg
Western Blot: Transferrin Receptor Overexpression Lysate (Native) [NBP2-09467] - Transferrin Receptor Overexpression Lysate (Native) Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for TFRC.

Panoply™ Human TFRC Knockdown Stable Cell Line - CSC-DC015857 from Creative biogene

Category Cell Line
Species Human

TFRC Knockout Cell Line-HeLa - CSC-RT1891 from Creative biogene

Category Cell Line
Species Human

TFRC KO Cell Lysate-HeLa - CLKO-1746 from Creative biogene

Category Cell Lysate
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