TFRC

Gene Symbol TFRC
Entrez Gene 7037
Alt Symbol CD71, T9, TFR, TFR1, TR, TRFR, p90
Species Human
Gene Type protein-coding
Description transferrin receptor
Other Description transferrin receptor (p90, CD71)|transferrin receptor protein 1
Swissprots Q9UDF9 Q1HE24 Q9UCN0 Q59G55 Q9UCU5 D3DXB0 P02786 Q9UK21
Accessions AAF04564 ABF47088 EAW53670 EAW53671 EAW53672 EAW53673 P02786 AB209254 BAD92491 AK291723 BAF84412 AK294758 BAH11872 AK309923 BC001188 AAH01188 BX537966 CAD97930 CK724857 DA460386 DQ892859 ABM83785 DQ896108 ABM87107 DT219054 M11507 AAA61153 X01060 CAA25527 XM_011513112 XP_011511414 NM_001128148 NP_001121620 NM_003234 NP_003225
Function Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. {ECO:0000250, ECO:0000269|PubMed:3568132}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:17081065}; Single-pass type II membrane protein {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Top Pathways Hematopoietic cell lineage, Endocytosis, Phagosome

CD71 (D7G9X) XP ® Rabbit mAb - 13113 from Cell Signaling Technology

Prices $109.00, $277.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D7G9X
Western blot analysis of extracts from various cell lines using CD71 (D7G9X) XP ® Rabbit mAb.

CD71 (D7S5Z) Rabbit mAb - 13208 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D7S5Z
Western blot analysis of extracts from ZR-75-1, HeLa, and HT-1080 cells using CD71 (D7S5Z) Rabbit mAb.

CD71 (G-8) - sc-393719 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD71 (G-8): sc-393719. Western blot analysis of CD71 expression in non-transfected: sc-117752 (A) and human CD71 transfected: sc-175273 (B) 293T whole cell lysates.

CD71 (H-300) - sc-9099 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
CD71 (H-300): sc-9099. Western blot analysis of CD71 expression in untreated (A), PMA-treated (B) and IL-2-treated (C) Jurkat whole cell lysates.

CD71 (C-20) - sc-7087 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CD71 (C-20): sc-7087. Western blot analysis of CD71 expression in CCRF-CEM whole cell lysate.

CD71 (DF1513) - sc-7327 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD71 (DF1513): sc-7327. Immunoperoxidase staining of formalin fixed, paraffin-embedded human placenta tissue showing cytoplasmic and membrane staining of decidual cells.

CD71 (3B8 2A1) - sc-32272 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD71 (3B8 2A1): sc-32272. Western blot analysis of CD71 expression in non-transfected: sc-117752 (A) and human CD71 transfected: sc-175273 (B) 293T whole cell lysates.

CD71 (T56/14) - sc-59111 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD71 (T56/14): sc-59111. Western blot analysis of CD71 expression in K-562 (A) and CCRF-CEM (B) whole cell lysates.

CD71 (b3/25) - sc-65877 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD71 (b3/25): sc-65877. Western blot analysis of CD71 expression in K-562 (A) and CCRF-CEM (B) whole cell lysates.

CD71 (H68.4) - sc-65882 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD71 (H68.4): sc-65882. Western blot analysis of CD71 expression in K-562 (A), CCRF-CEM (B), HeLa (C) and U-937 (D) whole cell lysates.

CD71 (Ber-T9) - sc-19675 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD71 (Ber-T9) FITC: sc-19675 FITC. FCM analysis of PMA-stimulated Jurkat cells. Black line histogram represents the isotype control, normal mouse IgG<sub>1</sub>: sc-2855.

CD71 (2B6) - sc-51829 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
CD71 (2B6): sc-51829. Western blot analysis of CD71 expression in CCRF-CEM (A), Jurkat (B), K-562 (C), MCF7 (D) and SJRH30 (E) whole cell lysates.

Anti-CD71 antibody [66IG10] - ab194402 from Abcam

Prices $370.00
Sizes 500 µl
Host Mouse
Clonality Monoclonal
Clone 66IG10

Anti-CD71 antibody [DF 1513 (Workshop IV)] - ab116015 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone DF 1513 (Workshop IV)

Anti-CD71 antibody [DF 1513 (Workshop IV)] (FITC) - ab116021 from Abcam

Prices $370.00
Sizes 1 ml
Host Mouse
Clonality Monoclonal
Clone DF 1513 (Workshop IV)

Anti-CD71 antibody [FG2/12] (CF405M) - ab115782 from Abcam

Prices $216.00
Sizes 50 tests
Host Mouse
Clonality Monoclonal
Clone FG2/12
ab115782 at 5µl/106 cells staining CD71 in K562 cells by Flow Cytometry (shown in yellow). Isotype control (blue).

Anti-Transferrin Receptor (phospho S24) antibody - ab61021 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded human brain tissue using ab61021 at a dilution of 1/50.

Anti-Transferrin Receptor antibody - ab84036 from Abcam

Prices $398.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Transferrin Receptor antibody (ab84036) at 1 µg/mlLane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell LysateLane 2 : Jurkat (Human T cell lymphoblast-like cell line) Whole Cell LysateLane 3 : U2OS (Human osteosarcoma cell line) Whole Cell Lysate Lysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-Transferrin Receptor antibody - ab166929 from Abcam

Prices $376.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-Transferrin Receptor antibody (ab166929) at 1 µg/ml + Human Breast lysate at 35 µgdeveloped using the ECL technique

Anti-Transferrin Receptor antibody - ab137844 from Abcam

Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin embedded Placenta tissue, labelling Transferrin Receptor with ab137844 at 10 µg/ml.

Anti-Transferrin Receptor antibody - ab61134 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab61134 stained DU145 cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab61134 at 10µg/ml overnight at +4°C. The secondary antibody (green) was DyLight® 488 goat anti- rabbit (ab96899) IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-Transferrin Receptor antibody - ab193188 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Transferrin Receptor antibody (ab193188) at 2 µg/ml (Transferrin receptor)SecondaryGoat polyclonal to Rabbit IgG at 1/10000 dilution

Anti-Transferrin Receptor antibody - ab124209 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Transferrin Receptor antibody (ab124209) at 1 µg/mlLane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell LysateLane 2 : Jurkat (Human T cell lymphoblast-like cell line) Whole Cell LysateLane 3 : U2OS (Human osteosarcoma cell line) Whole Cell LysateLane 4 : HEK293 (Human embryonic kidney cell line) Whole Cell LysateLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-Transferrin Receptor antibody - ab190258 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Transferrin Receptor antibody (ab190258) at 0.1 µg/mlLane 1 : HeLa whole cell lysateLane 2 : 293T whole cell lysateLane 3 : Jurkat whole cell lysateLane 4 : TCMK whole cell lysateLane 5 : NIH3T3 whole cell lysateLysates/proteins at 50 µg per lane.developed using the ECL technique

Anti-Transferrin Receptor antibody [10F11] - ab49517 from Abcam

Prices $372.00
Sizes 500 µg
Host Mouse
Clonality Monoclonal
Clone 10F11
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