TFRC

Gene Symbol	TFRC
Entrez Gene	7037
Alt Symbol	CD71, T9, TFR, TFR1, TR, TRFR, p90
Species	Human
Gene Type	protein-coding
Description	transferrin receptor
Other Description	transferrin receptor (p90, CD71)|transferrin receptor protein 1
Swissprots	Q9UDF9 Q1HE24 Q9UCN0 Q59G55 Q9UCU5 D3DXB0 P02786 Q9UK21
Accessions	AAF04564 ABF47088 EAW53670 EAW53671 EAW53672 EAW53673 P02786 AB209254 BAD92491 AK291723 BAF84412 AK294758 BAH11872 AK309923 BC001188 AAH01188 BX537966 CAD97930 CK724857 DA460386 DQ892859 ABM83785 DQ896108 ABM87107 DT219054 M11507 AAA61153 X01060 CAA25527 XM_011513112 XP_011511414 NM_001128148 NP_001121620 NM_003234 NP_003225
Function	Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. {ECO:0000250, ECO:0000269|PubMed:3568132}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:17081065}; Single-pass type II membrane protein {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Top Pathways	Hematopoietic cell lineage, Endocytosis, Phagosome

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Transferrin Receptor protein fragment - ab182678 from Abcam Category Protein Prices $357.00 Sizes 100 µg Source HEK 293 cells Species Human

Human Transferrin Receptor peptide - ab101219 from Abcam Category Peptide

Human Transferrin Receptor protein fragment - ab159687 from Abcam Category Protein Source Wheat germ Species Human

Human Transferrin Receptor protein fragment - ab202198 from Abcam Category Protein Source E. coli Species Human

CD71 / Transferrin Receptor Antibody Blocking Peptide - LS-E7226 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CD71 / Transferrin Receptor Antibody Blocking Peptide - LS-E23241 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CD71 / Transferrin Receptor Antibody Blocking Peptide - LS-E23240 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CD71 / Transferrin Receptor Antibody Blocking Peptide - LS-E28043 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human TfR (Transferrin R) Protein - H00007037-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Source Wheat Germ Species Human

Apo-Transferrin Native Protein - NBP1-99180 from Novus Biologicals Category Protein Prices $99.00 Sizes 100 mg Source Human

TfR (Transferrin R) Recombinant Protein - H00007037-G01 from Novus Biologicals Category Protein Prices $579.00 Sizes 10 µg Species Human

CD71-Antibody-C-term-Blocking-Peptide - BP2949b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human TfR, CF - 2474-TR-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Cys89-Phe760, with an N-terminal 6-His tag

Soluble Transferrin Receptor Protein (OPMA04326) - OPMA04326 from Aviva Systems Biology Category Protein Prices $1,010.00 Sizes 100 µg Source Human Blood

NATIVE Human CD71 Protein (OPSA10613) - OPSA10613 from Aviva Systems Biology Category Protein Prices $280.00 Sizes 20 µg Species Human

NATIVE Human CD71 Protein (OPSA10614) - OPSA10614 from Aviva Systems Biology Category Protein Prices $1,290.00 Sizes 200 µg Species Human

Human sTfR protein - orb245320 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Cynomolgus TFRC protein (His Tag) - orb139726 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Human Cells

Soluble Transferrin Receptor protein - orb82245 from Biorbyt Category Protein Prices $1,088.00 Sizes 100 μg Source Sample obtained from Human Blood. Species Human

Transferrin Receptor protein - orb79694 from Biorbyt Category Protein Prices $1,207.00 Sizes 100 µg

Human CD71 His tag protein - orb84157 from Biorbyt Category Protein Prices $510.00, $748.00 Sizes 50 μg, 100 μg Source Human Species Human

TFRC protein (His tag) - 80R-4118 from Fitzgerald Category Protein Prices $275.00 Sizes 100 µg Source E.coli

Transferrin Receptor protein - 30R-AT026X from Fitzgerald Category Protein Prices $787.50 Sizes 100 µg

Transferrin Receptor protein - 30-1226 from Fitzgerald Category Protein Prices $95.00 Sizes 10 µg Species Human

Transferrin Receptor protein (concentrate) - 30R-AT025 from Fitzgerald Category Protein Species Human

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