TFRC

Gene Symbol	TFRC
Entrez Gene	7037
Alt Symbol	CD71, T9, TFR, TFR1, TR, TRFR, p90
Species	Human
Gene Type	protein-coding
Description	transferrin receptor
Other Description	transferrin receptor (p90, CD71)|transferrin receptor protein 1
Swissprots	Q9UDF9 Q1HE24 Q9UCN0 Q59G55 Q9UCU5 D3DXB0 P02786 Q9UK21
Accessions	AAF04564 ABF47088 EAW53670 EAW53671 EAW53672 EAW53673 P02786 AB209254 BAD92491 AK291723 BAF84412 AK294758 BAH11872 AK309923 BC001188 AAH01188 BX537966 CAD97930 CK724857 DA460386 DQ892859 ABM83785 DQ896108 ABM87107 DT219054 M11507 AAA61153 X01060 CAA25527 XM_011513112 XP_011511414 NM_001128148 NP_001121620 NM_003234 NP_003225
Function	Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. {ECO:0000250, ECO:0000269|PubMed:3568132}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:17081065}; Single-pass type II membrane protein {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Top Pathways	Hematopoietic cell lineage, Endocytosis, Phagosome

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human TFRC gene - orb91562 from Biorbyt Prices $519.00 Sizes 10 μg Species Human

TFRC - MBS1270061 from MyBioSource Species Human Accession BC001188

Human TFRC cDNA clone(NM_001128148.1) - CDFH019520 from Creative Biomart Species Human Accession NM_001128148.1

Human TFRC ORF clone(NM_001128148.1) - CDCL186402 from Creative Biomart Species Human Accession NM_001128148.1

Human TFRC ORF Clone(NM_001128148.1) - CDCL178313 from Creative Biomart Species Human Accession NM_001128148.1

Human TFRC ORF Clone(NM_001128148.1) - CDCR348947 from Creative Biomart Species Human Accession NM_001128148.1

Human TFRC ORF Clone(NM_001128148.1) - CDCR348948 from Creative Biomart Species Human Accession NM_001128148.1

human TFRC ORF clone - CDCH090518 from Creative Biomart Species Human Accession NM_001128148

human TFRC ORF clone - CDCH090519 from Creative Biomart Species Human Accession NM_001128148

human TFRC ORF clone - CDCH090520 from Creative Biomart Species Human Accession NM_001128148

human TFRC ORF clone - CDCH090521 from Creative Biomart Species Human Accession NM_001128148

Human TFRC/CD71 Gene ORF cDNA clone in cloning vector - HG11020-M from Sino Biological Species Human

Human TFRC/CD71 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG11020-NF from Sino Biological Species Human

Human TFRC/CD71 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG11020-NM from Sino Biological Species Human

Human TFRC/CD71 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG11020-CF from Sino Biological Species Human

Human TFRC/CD71 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG11020-ACR from Sino Biological Species Human

Human TFRC/CD71 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG11020-CM from Sino Biological Species Human

Human TFRC/CD71 Gene ORF cDNA clone expression plasmid, C-HA tag - HG11020-CY from Sino Biological Species Human

Human TFRC/CD71 Gene ORF cDNA clone expression plasmid, N-HA tag - HG11020-NY from Sino Biological Species Human

Human TFRC/CD71 Gene ORF cDNA clone expression plasmid, N-His tag - HG11020-NH from Sino Biological Species Human

Human TFRC/CD71 Gene ORF cDNA clone expression plasmid - HG11020-UT from Sino Biological Species Human

Human TFRC Gene cDNA Clone (full-length ORF Clone), expression ready, C-His-tagged - HG11020-CH from Sino Biological Species Human Accession NM_001128148.1

Human TFRC/CD71 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG11020-ACG from Sino Biological Species Human

Human TfR (Transferrin R) (NP_003225) VersaClone cDNA - RDC1367 from R&D Systems Prices $499.00 Sizes 10 µg Species Human

Human TFRC ORF clone(NM_001128148.1) - CDCL186402 from Creative biogene Species Human

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