TFRC

Gene Symbol TFRC
Entrez Gene 7037
Alt Symbol CD71, T9, TFR, TFR1, TR, TRFR, p90
Species Human
Gene Type protein-coding
Description transferrin receptor
Other Description transferrin receptor (p90, CD71)|transferrin receptor protein 1
Swissprots Q9UDF9 Q1HE24 Q9UCN0 Q59G55 Q9UCU5 D3DXB0 P02786 Q9UK21
Accessions AAF04564 ABF47088 EAW53670 EAW53671 EAW53672 EAW53673 P02786 AB209254 BAD92491 AK291723 BAF84412 AK294758 BAH11872 AK309923 BC001188 AAH01188 BX537966 CAD97930 CK724857 DA460386 DQ892859 ABM83785 DQ896108 ABM87107 DT219054 M11507 AAA61153 X01060 CAA25527 XM_011513112 XP_011511414 NM_001128148 NP_001121620 NM_003234 NP_003225
Function Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. {ECO:0000250, ECO:0000269|PubMed:3568132}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:17081065}; Single-pass type II membrane protein {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Top Pathways Hematopoietic cell lineage, Endocytosis, Phagosome

CD71 CRISPR/Cas9 KO Plasmid (h) - sc-400310 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CD71 HDR Plasmid (h) - sc-400310-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CD71 Double Nickase Plasmid (h) - sc-400310-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CD71 Double Nickase Plasmid (h2) - sc-400310-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CD71 CRISPR Activation Plasmid (h) - sc-400310-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CD71 CRISPR Activation Plasmid (h2) - sc-400310-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CD71 Lentiviral Activation Particles (h) - sc-400310-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CD71 Lentiviral Activation Particles (h2) - sc-400310-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CD71 siRNA (h) - sc-37070 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CD71 shRNA Plasmid (h) - sc-37070-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CD71 shRNA (h) Lentiviral Particles - sc-37070-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TfR (Transferrin R) RNAi - H00007037-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU078971 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN21268 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21268 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR11513 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr11513

TFRC siRNA (Human) - CRH4810 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TFRC - MBS8206432 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human TFRC (NM_003234.2) - SHH426320 from Creative biogene

Category siRNA
Species Reactivities Human

Human CD71 siRNA - orb265312 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TFRC shRNA Plasmid (Human) - CHH4810 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

TFRC miRNA 3'UTR clone - MiUTR1H-10348 from Creative biogene

Species Reactivities Human

TFRC miRNA 3'UTR clone - MiUTR1H-10349 from Creative biogene

Species Reactivities Human
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