| Gene Symbol |
THBD
|
| Entrez Gene |
7056
|
| Alt Symbol |
AHUS6, BDCA3, CD141, THPH12, THRM, TM
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
thrombomodulin
|
| Other Description |
CD141 antigen|fetomodulin
|
| Swissprots |
Q8IV29 P07204 Q9UC32
|
| Accessions |
AAA61175 AAM03232 BAA00149 EAX10172 P07204 AI285986 AK091934 AK123557 BAG53913 BC035602 AAH35602 BC053357 AAH53357 BG771668 M16552 AAB59508 X05495 CAA29045 NM_000361 NP_000352
|
| Function |
Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.
|
| Subcellular Location |
Membrane; Single-pass type I membrane protein.
|
| Tissue Specificity |
Endothelial cells are unique in synthesizing thrombomodulin.
|
| Top Pathways |
Complement and coagulation cascades
|