THBD

Gene Symbol	THBD
Entrez Gene	7056
Alt Symbol	AHUS6, BDCA3, CD141, THPH12, THRM, TM
Species	Human
Gene Type	protein-coding
Description	thrombomodulin
Other Description	CD141 antigen|fetomodulin
Swissprots	Q8IV29 P07204 Q9UC32
Accessions	AAA61175 AAM03232 BAA00149 EAX10172 P07204 AI285986 AK091934 AK123557 BAG53913 BC035602 AAH35602 BC053357 AAH53357 BG771668 M16552 AAB59508 X05495 CAA29045 NM_000361 NP_000352
Function	Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.
Subcellular Location	Membrane; Single-pass type I membrane protein.
Tissue Specificity	Endothelial cells are unique in synthesizing thrombomodulin.
Top Pathways	Complement and coagulation cascades

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

TM CRISPR/Cas9 KO Plasmid (h) - sc-400956 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

TM HDR Plasmid (h) - sc-400956-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TM Double Nickase Plasmid (h) - sc-400956-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TM Double Nickase Plasmid (h2) - sc-400956-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TM CRISPR Activation Plasmid (h) - sc-400956-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

TM CRISPR Activation Plasmid (h2) - sc-400956-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

TM Lentiviral Activation Particles (h) - sc-400956-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TM Lentiviral Activation Particles (h2) - sc-400956-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TM siRNA (h) - sc-36686 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

TM shRNA Plasmid (h) - sc-36686-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

TM shRNA (h) Lentiviral Particles - sc-36686-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Thrombomodulin/BDCA-3 RNAi - H00007056-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU000321 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN21302 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21302 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR11108 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr11108

THBD siRNA (Human) - CRH4828 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

THBD - MBS8235743 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

TM CRISPR/Cas9 KO Plasmid (h2) - sc-400956-KO-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

TM HDR Plasmid (h2) - sc-400956-HDR-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

shRNA set against Human THBD(NM_000361.2) - SHL068660 from Creative biogene Category siRNA Species Reactivities Human

Human THBD siRNA - orb265330 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

THBD shRNA Plasmid (Human) - CHH4828 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

THBD miRNA 3'UTR clone - MiUTR1H-10375 from Creative biogene Species Reactivities Human

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