THBD

Gene Symbol	THBD
Entrez Gene	7056
Alt Symbol	AHUS6, BDCA3, CD141, THPH12, THRM, TM
Species	Human
Gene Type	protein-coding
Description	thrombomodulin
Other Description	CD141 antigen|fetomodulin
Swissprots	Q8IV29 P07204 Q9UC32
Accessions	AAA61175 AAM03232 BAA00149 EAX10172 P07204 AI285986 AK091934 AK123557 BAG53913 BC035602 AAH35602 BC053357 AAH53357 BG771668 M16552 AAB59508 X05495 CAA29045 NM_000361 NP_000352
Function	Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.
Subcellular Location	Membrane; Single-pass type I membrane protein.
Tissue Specificity	Endothelial cells are unique in synthesizing thrombomodulin.
Top Pathways	Complement and coagulation cascades

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Thrombomodulin protein fragment - ab117215 from Abcam Category Protein Prices $465.00 Sizes 10 µg Source HEK 293 cells Species Human

Active human Thrombomodulin protein fragment - ab98989 from Abcam Category Protein Prices $110.00, $302.00 Sizes 2 µg, 10 µg Source HEK 293 cells Species Human

Active rabbit Thrombomodulin full length protein - ab88556 from Abcam Category Protein Prices $522.00 Sizes 50 µg Source Native Species Rabbit

HIV1 gp120 + gp41 + HIV2 gp 39 protein fragment - ab68872 from Abcam Category Protein Prices $192.00 Sizes 100 µg Source E. coli

HIV1 gp120 + gp41 peptide - ab49059 from Abcam Category Peptide Prices $290.00 Sizes 100 µg

HIV1 gp120 + gp41 protein fragment - ab49054 from Abcam Category Protein Prices $192.00 Sizes 100 µg Source E. coli

HIV1 gp120 + gp41 protein fragment - ab68127 from Abcam Category Protein Prices $192.00 Sizes 100 µg Source E. coli

Human Thrombomodulin full length protein - ab177225 from Abcam Category Protein Source Wheat germ Species Human

Thrombomodulin peptide - ab106425 from Abcam Category Peptide

Thrombomodulin/BDCA-3 Recombinant Protein - H00007056-G01 from Novus Biologicals Category Protein Prices $579.00 Sizes 10 µg Species Human

Thrombomodulin-Antibody-Center-Blocking-Peptide - BP6779c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Thrombomodulin Recombinant Protein (Active) - GTX48126-PRO from GeneTex Category Protein Prices $299.00 Sizes 10 μg Source Human Species Human

Recombinant Human Thrombomodulin/BDCA-3, CF - 3947-PA-010 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Ala19-Ser515, with a C-terminal 6-His tag

Human CD141 Protein (OPSA11771) - OPSA11771 from Aviva Systems Biology Category Protein Prices $430.00 Sizes 10 µg Species Human

Thrombomodulin protein - 80R-4191 from Fitzgerald Category Protein Prices $1,395.00 Sizes 500 µg Source E.coli Species Human

Thrombomodulin protein - 30R-3336 from Fitzgerald Category Protein Prices $1,295.00 Sizes 100 µg

CD141 Blocking Peptide - abx063354 from Abbexa Category Peptide Species Human, Mouse, Rat

Human Thrombomodulin Protein - abx069274 from Abbexa Category Protein Source E.coli Species Human

CD141 / THBD - AR09440PU-N from Acris Antibodies Category Protein Prices $235.00 Sizes 10 µg Source HEK293 cells Species Human

CD141 / THBD - AR09440PU-S from Acris Antibodies Category Protein Prices $135.00 Sizes 2 µg Source HEK293 cells Species Human

CD141 / THBD - H00007056-G01 from Acris Antibodies Category Protein Prices $550.00 Sizes 10 µg Species Human

CD141 / THBD - P6035 from Acris Antibodies Category Protein Prices $580.00 Sizes 10 µg Species Human

Thrombomodulin, Recombinant Human - 213-10434-1 from RayBiotech Category Protein Prices $75.00 Sizes 1 µg Source HEK293 cells Species Human

Recombinant Human Thrombomodulin - 213-10434-2 from RayBiotech Category Protein Prices $190.00 Sizes 2 µg Source HEK293 cells Species Human

Thrombomodulin (TM), Human - 20-6743 from ARP American Research Products Category Protein Prices $549.00 Sizes 50 µg Source E.coli Species Human

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