THBD

Gene Symbol THBD
Entrez Gene 7056
Alt Symbol AHUS6, BDCA3, CD141, THPH12, THRM, TM
Species Human
Gene Type protein-coding
Description thrombomodulin
Other Description CD141 antigen|fetomodulin
Swissprots Q8IV29 P07204 Q9UC32
Accessions AAA61175 AAM03232 BAA00149 EAX10172 P07204 AI285986 AK091934 AK123557 BAG53913 BC035602 AAH35602 BC053357 AAH53357 BG771668 M16552 AAB59508 X05495 CAA29045 NM_000361 NP_000352
Function Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.
Subcellular Location Membrane; Single-pass type I membrane protein.
Tissue Specificity Endothelial cells are unique in synthesizing thrombomodulin.
Top Pathways Complement and coagulation cascades

TM (H-11) - sc-271804 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TM (H-11): sc-271804. Western blot analysis of TM expression in non-transfected: sc-117752 (A) and human TM transfected: sc-115666 (B) 293T whole cell lysates.

TM (H-300) - sc-9162 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
TM (H-300): sc-9162. Immunofluorescence staining of normal mouse intestine frozen section showing membrane staining.

TM (M-17) - sc-7097 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TM (M-17): sc-7097. Western blot analysis of thrombo-modulin expression in A549 (A) and AML-193 (B) whole cell lysates.

TM (C-17) - sc-7096 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TM (C-17): sc-7096. Western blot analysis of thrombo-modulin expression in A549 (A) and AML-193 (B) whole cell lysates.

TM (D-3) - sc-13164 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TM (D-3): sc-13164. Western blot analysis of TM expression in THP-1 whole cell lysate.

Anti-Thrombomodulin antibody - ab94373 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Thrombomodulin antibody (ab94373) at 1 µg/mlLane 1 : Heart (Human) Tissue Lysate - adult normal tissue (ab29431)Lane 2 : Lung (Human) Tissue LysateLane 3 : Kidney (Human) Tissue Lysate - adult normal tissue (ab30203)Lane 4 : Placenta (Human) Tissue Lysate - adult normal tissue (ab29745)Lysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-Thrombomodulin antibody [0.N.186] - ab33513 from Abcam

Prices $370.00
Sizes 250 µl
Host Mouse
Clonality Monoclonal
Clone 0.N.186

Anti-Thrombomodulin antibody [141C01], prediluted - ab74603 from Abcam

Prices $370.00
Sizes 7 ml
Host Mouse
Clonality Monoclonal
Clone 141C01

Anti-Thrombomodulin antibody [B-A35] - ab27393 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone B-A35
A typical staining pattern with the ab27393 of monocytes

Anti-Thrombomodulin antibody [B-A35] - ab27350 from Abcam

Prices $376.00
Sizes 2 ml
Host Mouse
Clonality Monoclonal
Clone B-A35
A typical staining pattern of human monocytes from whole blood with ab27350.

Anti-Thrombomodulin antibody [B-A35] (FITC) - ab27396 from Abcam

Prices $188.00
Sizes 50 tests
Host Mouse
Clonality Monoclonal
Clone B-A35
A typical staining pattern with ab27396 of monocytes

Anti-Thrombomodulin antibody [EPR4051] - ab109189 from Abcam

Prices $397.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4051
All lanes : Anti-Thrombomodulin antibody [EPR4051] (ab109189) at 1/1000 dilutionLane 1 : THP-1 cell lysateLane 2 : Human placenta lysateLane 3 : Human heart lysateLysates/proteins at 10 µg per lane.

Anti-Thrombomodulin antibody [PBS-01] - ab6980 from Abcam

Prices $398.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone PBS-01
Ab6980 staining human normal lung endothelium. Staining is localized to the membrane.Left panel: with primary antibody at 1 ug/ml. Right panel: isotype control.Sections were stained using an automated system DAKO Autostainer Plus , at room temperature. Sections were rehydrated and antigen retrieved with the Dako 3-in-1 AR buffer EDTA pH 9.0 in a DAKO PT Link. Slides were peroxidase blocked in 3% H2O2 in methanol for 10 minutes. They were then blocked with Dako Protein block for 10 minutes (containing casein 0.25% in PBS), then incubated with primary antibody for 20 minutes, and detected with Dako Envision Flex amplification kit for 30 minutes. Colorimetric detection was completed with diaminobenzidine for 5 minutes. Slides were counterstained with Haematoxylin and coverslipped under DePeX. Please note that for manual staining we recommend to optimize the primary antibody concentration and incubation time (overnight incubation), and amplification may be required.

Anti-Thrombomodulin antibody [PBS-02] - ab7640 from Abcam

Prices $379.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone PBS-02
ab7640 (1µg/ml) staining thrmbomodulin in human lung using an automated system (DAKO Autostainer Plus). Using this protocol there is strong membrane staining of pneumocytes.Sections were rehydrated and antigen retrieved with the Dako 3 in 1 AR buffer EDTA pH 9.0 in a DAKO PT link. Slides were peroxidase blocked in 3% H2O2 in methanol for 10 mins. They were then blocked with Dako Protein block for 10 minutes (containing casein 0.25% in PBS) then incubated with primary antibody for 20 min and detected with Dako Envision Flex amplification kit for 30 minutes. Colorimetric detection was completed with Diaminobenzidine for 5 minutes. Slides were counterstained with Haematoxylin and coverslipped under DePeX. Please note that, for manual staining, optimization of primary antibody concentration and incubation time is recommended. Signal amplification may be required.

Anti-Thrombomodulin antibody [Phx-01] - ab24595 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone Phx-01

Anti-Thrombomodulin antibody [Phx-02] - ab24598 from Abcam

Prices $373.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone Phx-02

Anti-Thrombomodulin antibody - C-terminal - ab138227 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Thrombomodulin antibody - C-terminal (ab138227) at 1/500 dilution + Hela cell lysates at 30 µg

Anti-THBD / CD141 / Thrombomodulin Antibody - LS-C125315 from LifeSpan Bioscience

Prices $650.00
Sizes 100 µg
Host Rat
Clonality Monoclonal

Anti-THBD / CD141 / Thrombomodulin Antibody (aa19-515, Biotin) - LS-C132432 from LifeSpan Bioscience

Prices $650.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-THBD / CD141 / Thrombomodulin Antibody - LS-C125316 from LifeSpan Bioscience

Prices $620.00
Sizes 100 µg
Host Rat
Clonality Monoclonal

Anti-THBD / CD141 / Thrombomodulin Antibody (clone RTM96) - LS-C140066 from LifeSpan Bioscience

Prices $515.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone RTM96

Anti-THBD / CD141 / Thrombomodulin Antibody (aa17-517) - LS-C150259 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-THBD / CD141 / Thrombomodulin Antibody (clone RTM98) - LS-C140067 from LifeSpan Bioscience

Prices $515.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone RTM98

Anti-THBD / CD141 / Thrombomodulin Antibody (Leu575) - LS-C193242 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-THBD / CD141 / Thrombomodulin Antibody (clone QBEND/40) - LS-C204169 from LifeSpan Bioscience

Prices $455.00
Sizes 100 tst
Host Mouse
Clonality Monoclonal
Clone QBEND/40
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