MBD2

Gene Symbol MBD2
Entrez Gene 8932
Alt Symbol DMTase, NY-CO-41
Species Human
Gene Type protein-coding
Description methyl-CpG binding domain protein 2
Other Description demethylase|methyl-CpG-binding domain protein 2
Swissprots Q9UIS8 Q9UBB5 O95242
Accessions AAD56596 AAD56597 EAW62997 EAW62998 EAW62999 Q9UBB5 AF039701 AAC18050 AF072242 AAC68871 AF072246 AAC68875 AF072252 AL110266 CAH10725 AW151547 AW274866 BC032638 AAH32638 BE540652 BQ228712 NM_003927 NP_003918 NM_015832 NP_056647
Function Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters. {ECO:0000269|PubMed:10471499, ECO:0000269|PubMed:10947852, ECO:0000269|PubMed:12665568, ECO:0000269|PubMed:16415179, ECO:0000269|PubMed:24307175, ECO:0000269|PubMed:9774669}.
Subcellular Location Nucleus {ECO:0000269|PubMed:12183469, ECO:0000269|PubMed:9774669}. Note=Nuclear, in discrete foci. Detected at replication foci in late S phase.
Tissue Specificity Highly expressed in brain, heart, kidney, stomach, testis and placenta. {ECO:0000269|PubMed:10050851}.

demethylase, ELISA Kit - MBS267841 from MyBioSource

Category ELISA Kit
Prices $275.00, $420.00, $1,615.00, $2,880.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

MBD2, ELISA Kit - MBS2516237 from MyBioSource

Category ELISA Kit
Prices $410.00, $490.00, $2,040.00, $3,590.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.094ng/mL
Range 0.156-10ng/mL

methyl-CpG binding domain protein 2, ELISA Kit - MBS9327340 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

MBD2 Binding Activity/Inhibition Assay Kit - KA0675 from Acris Antibodies

Category Assay Kit
Prices $650.00
Sizes 1 kit

Human MBD2 ELISA Kit (Sandwich ELISA) - LS-F21286 from LifeSpan Bioscience

Category ELISA Kit
Prices $590.00
Sizes 1 plate
Sensitivity 0.094 ng/ml
Range 0.156-10 ng/ml

Methyl CpG Binding Domain Protein 2Elisa Kit, MBD2, Human, ELISA Kit - E-EL-H5425 from ARP American Research Products

Category ELISA Kit
Prices $522.00
Sizes 96 t
Sensitivity 0.094
Range 0.156-10ng/mL
Methyl CpG Binding Domain Protein 2Elisa Kit, MBD2, Human, ELISA Kit

MBD2 ELISA Kit (Human) (OKEI00316) - OKEI00316 from Aviva Systems Biology

Category ELISA Kit
Sensitivity 0.094 ng/mL
Range 0.156 - 10 ng/mL
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