MBD2

Gene Symbol	MBD2
Entrez Gene	8932
Alt Symbol	DMTase, NY-CO-41
Species	Human
Gene Type	protein-coding
Description	methyl-CpG binding domain protein 2
Other Description	demethylase|methyl-CpG-binding domain protein 2
Swissprots	Q9UIS8 Q9UBB5 O95242
Accessions	AAD56596 AAD56597 EAW62997 EAW62998 EAW62999 Q9UBB5 AF039701 AAC18050 AF072242 AAC68871 AF072246 AAC68875 AF072252 AL110266 CAH10725 AW151547 AW274866 BC032638 AAH32638 BE540652 BQ228712 NM_003927 NP_003918 NM_015832 NP_056647
Function	Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters. {ECO:0000269|PubMed:10471499, ECO:0000269|PubMed:10947852, ECO:0000269|PubMed:12665568, ECO:0000269|PubMed:16415179, ECO:0000269|PubMed:24307175, ECO:0000269|PubMed:9774669}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:12183469, ECO:0000269|PubMed:9774669}. Note=Nuclear, in discrete foci. Detected at replication foci in late S phase.
Tissue Specificity	Highly expressed in brain, heart, kidney, stomach, testis and placenta. {ECO:0000269|PubMed:10050851}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

MBD2-Antibody-N-term-Blocking-Peptide - BP1067a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MBD2 (isoform 1) blocking peptide - GTX89182-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat

MBD2 Peptide - AC21-1053-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

MBD2 Peptide - 45-868P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

Recombinant Methyl CpG Binding Domain Protein 2 (MBD2) - RPC207Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Methyl CpG Binding Domain Protein 2 (MBD2) - RPC207Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Methyl-CpG-binding domain protein 2(MBD2) - CSB-YP890654HU CSB-EP890654HU CSB-BP890654HU CSB-MP890654HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

MBD2, Peptide - MBS425651 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Dog

MBD2-Antibody-C-term-Blocking-Peptide - BP1067b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MBD2-Blocking-Peptide-Center - BP19883C from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MBD2 Recombinant Protein (OPCD05150) - OPCD05150 from Aviva Systems Biology Category Protein Source E.coli Species Human

Methyl CpG Binding Domain Protein 2, Recombinant Protein - MBS2030935 from MyBioSource Category Protein Prices $185.00, $385.00, $595.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Human

Methyl-CpG-binding domain protein 2 (MBD2), Recombinant Protein - MBS1485404 from MyBioSource Category Protein Prices $1,185.00, $1,185.00, $1,405.00, $1,405.00, $1,905.00, $1,905.00, $2,370.00, $2,370.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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