MBD2

Gene Symbol MBD2
Entrez Gene 8932
Alt Symbol DMTase, NY-CO-41
Species Human
Gene Type protein-coding
Description methyl-CpG binding domain protein 2
Other Description demethylase|methyl-CpG-binding domain protein 2
Swissprots Q9UIS8 Q9UBB5 O95242
Accessions AAD56596 AAD56597 EAW62997 EAW62998 EAW62999 Q9UBB5 AF039701 AAC18050 AF072242 AAC68871 AF072246 AAC68875 AF072252 AL110266 CAH10725 AW151547 AW274866 BC032638 AAH32638 BE540652 BQ228712 NM_003927 NP_003918 NM_015832 NP_056647
Function Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters. {ECO:0000269|PubMed:10471499, ECO:0000269|PubMed:10947852, ECO:0000269|PubMed:12665568, ECO:0000269|PubMed:16415179, ECO:0000269|PubMed:24307175, ECO:0000269|PubMed:9774669}.
Subcellular Location Nucleus {ECO:0000269|PubMed:12183469, ECO:0000269|PubMed:9774669}. Note=Nuclear, in discrete foci. Detected at replication foci in late S phase.
Tissue Specificity Highly expressed in brain, heart, kidney, stomach, testis and placenta. {ECO:0000269|PubMed:10050851}.

MBD2 CRISPR/Cas9 KO Plasmid (h) - sc-401561 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MBD2 HDR Plasmid (h) - sc-401561-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MBD2 Double Nickase Plasmid (h) - sc-401561-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MBD2 Double Nickase Plasmid (h2) - sc-401561-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MBD2 CRISPR Activation Plasmid (h) - sc-401561-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MBD2 CRISPR Activation Plasmid (h2) - sc-401561-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MBD2 Lentiviral Activation Particles (h) - sc-401561-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MBD2 Lentiviral Activation Particles (h2) - sc-401561-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MBD2 siRNA (h) - sc-35865 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MBD2 shRNA Plasmid (h) - sc-35865-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MBD2 shRNA (h) Lentiviral Particles - sc-35865-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MBD2 siRNA (h2) - sc-156060 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MBD2 shRNA Plasmid (h2) - sc-156060-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MBD2 shRNA (h2) Lentiviral Particles - sc-156060-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN13071 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13071 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MBD2 siRNA (Human) - CRH5906 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

MBD2 RNAi - H00008932-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MBD2 siRNA - orb219194 from Biorbyt

Category siRNA
Prices $417.00
Sizes 5 od (260 nm)
Species Reactivities Human

MBD2 shRNA Plasmid (Human) - CHH5906 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

MBD2 miRNA 3'UTR clone - MiUTR3H-06065 from Creative biogene

Species Reactivities Human

MBD2 miRNA 3'UTR clone - MiUTR3H-06066 from Creative biogene

Species Reactivities Human
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