MBD2

Gene Symbol MBD2
Entrez Gene 8932
Alt Symbol DMTase, NY-CO-41
Species Human
Gene Type protein-coding
Description methyl-CpG binding domain protein 2
Other Description demethylase|methyl-CpG-binding domain protein 2
Swissprots Q9UIS8 Q9UBB5 O95242
Accessions AAD56596 AAD56597 EAW62997 EAW62998 EAW62999 Q9UBB5 AF039701 AAC18050 AF072242 AAC68871 AF072246 AAC68875 AF072252 AL110266 CAH10725 AW151547 AW274866 BC032638 AAH32638 BE540652 BQ228712 NM_003927 NP_003918 NM_015832 NP_056647
Function Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters. {ECO:0000269|PubMed:10471499, ECO:0000269|PubMed:10947852, ECO:0000269|PubMed:12665568, ECO:0000269|PubMed:16415179, ECO:0000269|PubMed:24307175, ECO:0000269|PubMed:9774669}.
Subcellular Location Nucleus {ECO:0000269|PubMed:12183469, ECO:0000269|PubMed:9774669}. Note=Nuclear, in discrete foci. Detected at replication foci in late S phase.
Tissue Specificity Highly expressed in brain, heart, kidney, stomach, testis and placenta. {ECO:0000269|PubMed:10050851}.

Human MBD2 ORF clone(NM_003927.4) - CDCH388765 from Creative Biomart

Species Human
Accession NM_003927.4

Human MBD2 ORF clone(NM_003927.4) - CDCH388765 from Creative biogene

Species Human
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