| Gene Symbol |
MBD2
|
| Entrez Gene |
8932
|
| Alt Symbol |
DMTase, NY-CO-41
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
methyl-CpG binding domain protein 2
|
| Other Description |
demethylase|methyl-CpG-binding domain protein 2
|
| Swissprots |
Q9UIS8 Q9UBB5 O95242
|
| Accessions |
AAD56596 AAD56597 EAW62997 EAW62998 EAW62999 Q9UBB5 AF039701 AAC18050 AF072242 AAC68871 AF072246 AAC68875 AF072252 AL110266 CAH10725 AW151547 AW274866 BC032638 AAH32638 BE540652 BQ228712 NM_003927 NP_003918 NM_015832 NP_056647
|
| Function |
Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters. {ECO:0000269|PubMed:10471499, ECO:0000269|PubMed:10947852, ECO:0000269|PubMed:12665568, ECO:0000269|PubMed:16415179, ECO:0000269|PubMed:24307175, ECO:0000269|PubMed:9774669}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:12183469, ECO:0000269|PubMed:9774669}. Note=Nuclear, in discrete foci. Detected at replication foci in late S phase.
|
| Tissue Specificity |
Highly expressed in brain, heart, kidney, stomach, testis and placenta. {ECO:0000269|PubMed:10050851}.
|