MBD2

Gene Symbol MBD2
Entrez Gene 8932
Alt Symbol DMTase, NY-CO-41
Species Human
Gene Type protein-coding
Description methyl-CpG binding domain protein 2
Other Description demethylase|methyl-CpG-binding domain protein 2
Swissprots Q9UIS8 Q9UBB5 O95242
Accessions AAD56596 AAD56597 EAW62997 EAW62998 EAW62999 Q9UBB5 AF039701 AAC18050 AF072242 AAC68871 AF072246 AAC68875 AF072252 AL110266 CAH10725 AW151547 AW274866 BC032638 AAH32638 BE540652 BQ228712 NM_003927 NP_003918 NM_015832 NP_056647
Function Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters. {ECO:0000269|PubMed:10471499, ECO:0000269|PubMed:10947852, ECO:0000269|PubMed:12665568, ECO:0000269|PubMed:16415179, ECO:0000269|PubMed:24307175, ECO:0000269|PubMed:9774669}.
Subcellular Location Nucleus {ECO:0000269|PubMed:12183469, ECO:0000269|PubMed:9774669}. Note=Nuclear, in discrete foci. Detected at replication foci in late S phase.
Tissue Specificity Highly expressed in brain, heart, kidney, stomach, testis and placenta. {ECO:0000269|PubMed:10050851}.

MBD2 (C-11) - sc-514062 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MBD2 (C-11): sc-514062. Western blot analysis of MBD2 expression in A-431 (A), Jurkat (B) and HeLa (C) nuclear extracts.

MBD2 (D-15) - sc-12444 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
MBD2 (D-15): sc-12444. Western blot analysis of MBD2 expression in Jurkat nuclear extract.

MBD2 (H-70) - sc-10752 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
MBD2 (H-70): sc-10752. Western blot analysis of MBD2 expression in Jurkat nuclear extract.

MBD2 (N-18) - sc-9397 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
MBD2 (N-18): sc-9397. Western blot analysis of MBD2 expression in A-431 nuclear extract.

MBD2/3 (B-12) - sc-271522 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MBD2/3 (B-12): sc-271522. Western blot analysis of MBD2/3 expression in Jurkat nuclear extract.

MBD2/3 (D-7) - sc-271562 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MBD2/3 (D-7): sc-271562. Western blot analysis of MBD2/3 expression in Jurkat (A) and HeLa (B) nuclear extracts.

MBD2/3 (E-8) - sc-271521 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MBD2/3 (E-8): sc-271521. Western blot analysis of MBD2/3 expression in Jurkat nuclear extract.

Anti-MBD2 antibody - ab38646 from Abcam

Prices $395.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
ab38646 immunoprecipitating MBD2 in human K562 whole cell lysate. 15µg of cell lysate was incubated with primary antibody (2 µg/ml in RIPA buffer) and matrix (Protein A/G) for 12 hours at 4°C. For western blotting a HRP-conjugated goat anti-rabbit IgG polyclonal (1/2500) was used as the secondary antibody.See Abreview

Anti-MBD2 antibody - ab105323 from Abcam

Prices $384.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
ab105323, at 2.5 µg/ml, staining MBD2 in formalin-fixed, paraffin-embedded Human Adrenal tissue by Immunohistochemistry, using a biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-MBD2 antibody - ab58241 from Abcam

Prices $378.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-MBD2 antibody (ab58241) at 0.3 µg/ml + Jurkat cell lysate at 35 µg

Anti-MBD2 antibody - ab84753 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab84753 at 1/100 dilution staining MBD2 in human breast carcinoma by Immunohistochemistry/Immunofluorescence, Formalin-fixed, Paraffin-embedded tissue. Detection: Red-fluorescent goat anti-rabbit IgG highly cross-adsorbed Antibody Hilyte PlusTM 555 used at a dilution of 1:100.

Anti-MBD2 antibody - ab137777 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-MBD2 antibody (ab137777) at 1/1000 dilutionLane 1 : A431 whole cell lysateLane 2 : Jurkat whole cell lysateLane 3 : Raji whole cell lysateLysates/proteins at 30 µg per lane.

Anti-MBD2 antibody - ab80258 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-MBD2 antibody - ab26848 from Abcam

Host Chicken
Clonality Polyclonal
Free peptide as test antigen. ab26848 used as primary antibody, with an HRP-conjugated anti-IgY as secondary.

Anti-MBD2 antibody - ab49136 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-MBD2 antibody (ab49136) at 0.625 µg/ml + HepG2 cell lysate at 10 µg with 5% skimmed milk in PBSSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-MBD2 antibody [EPR3519] - ab109260 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3519
All lanes : Anti-MBD2 antibody [EPR3519] (ab109260) at 1/1000 dilutionLane 1 : A431 cell lysateLane 2 : HeLa cell lysateLane 3 : HT29 cell lysateLane 4 : A375 cell lysateLysates/proteins at 10 µg per lane.

Anti-MBD2a antibody - ab133196 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-MBD2a antibody (ab133196) at 4 µg/ml + Jurkat cell lysate

Anti-MBD2 Antibody - LS-C153169 from LifeSpan Bioscience

Prices $410.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MBD2 Antibody (Internal) - LS-C153492 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MBD2 Antibody (aa151-200) - LS-C30730 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
A: Marker, B: HepG2 Cell Lysate

Anti-MBD2 Antibody - LS-C183446 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MBD2 Antibody (aa187-200) - LS-C194008 from LifeSpan Bioscience

Prices $905.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MBD2 Antibody (aa250-279, AP) - LS-C237420 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MBD2 Antibody (aa250-279, APC) - LS-C237421 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MBD2 Antibody (N-Terminus) - LS-C109671 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
MBD2 antibody LS-C109671 Western blot of 721_B cell lysate.
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